Male | Female | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Exposure concentration (mg/m3) | 0 | 0.3 | 1 | 3 | 10 | 0 | 0.3 | 1 | 3 | 10 |
No. of animals examined | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
Initial sacrifice (Expo. 13w) | ||||||||||
Histopathological findings | ||||||||||
Mediastinal lymph node | ||||||||||
Lymphoid hyperplasia | 0 | 0 | 1 | 4* | 6** | 0 | 1 | 1 | 1 | 4* |
<1> | <1> | <1.3> | <1> | <1> | <1> | <1.3> | ||||
Lung | ||||||||||
Deposition of test compound (AB-positive material) | 0 | 8*** | 8*** | 8*** | 8*** | 0 | 8*** | 8*** | 8*** | 8*** |
<1> | <1> | <1> | <2> | <1> | < 1> | <2> | <2> | |||
Granulomatous change, alveolar | 0 | 0 | 8*** | 8*** | 8*** | 0 | 0 | 8*** | 8*** | 8*** |
<1> | <1.1> | <1.9> | <1> | <1> | <1.6> | |||||
Multifocal lesions, alveolar | ||||||||||
Hypertrophy/proliferation of alveolar epithelium | 0 | 0 | 3 | 8*** | 8*** | 0 | 0 | 6** | 8*** | 8*** |
<1> | <1.1> | <2> | <1> | <1> | <2> | |||||
Inflammation, air space | 0 | 0 | 6** | 8*** | 8*** | 0 | 0 | 6** | 8*** | 8*** |
<1> | <1.1> | <2> | <1> | <1> | <2> | |||||
Cholesterol creft, air space | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Alveolitis | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fibrous thickening, interstitial | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Accumulation of lipoproteinous material, air space | 0 | 0 | 0 | 2 | 8*** | 0 | 0 | 0 | 6** | 8*** |
<1> | <1.9> | <1> | <1.9> |