Male | Female | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Exposure concentration (mg/m3) | 0 | 0.3 | 1 | 3 | 10 | 0 | 0.3 | 1 | 3 | 10 |
No. of animals examined | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
13w recovery | ||||||||||
Histopathological findings | ||||||||||
Mediastinal lymph node | ||||||||||
Lymphoid hyperplasia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lung | ||||||||||
Deposition of test compound (AB-positive material) | 0 | 3 | 8*** | 8*** | 8*** | 0 | 3 | 8*** | 8*** | 8*** |
<1> | <1> | <1> | <2> | <1> | <1> | <1> | <2> | |||
Granulomatous change, alveolar | 0 | 0 | 8*** | 8*** | 8*** | 0 | 0 | 8*** | 8*** | 8*** |
<1> | <1> | <1> | <1> | <1> | <1.3> | |||||
Multifocal lesion, alveolar | ||||||||||
Hypertrophy/proliferation of alveolar epithelium | 0 | 0 | 0 | 6** | 8*** | 0 | 0 | 0 | 7*** | 8*** |
<1> | <1.8> | <1.1> | <1.8> | |||||||
Inflammation, air space | 0 | 0 | 0 | 8*** | 8*** | 0 | 0 | 0 | 8*** | 8*** |
<1> | <1> | <1.1> | <1> | |||||||
Cholesterol creft, air space | 0 | 0 | 0 | 1 | 8*** | 0 | 0 | 0 | 4* | 8*** |
<1> | <1> | <1> | <1.1> | |||||||
Alveolitis | 0 | 0 | 0 | 6** | 8*** | 0 | 0 | 0 | 6** | 8*** |
<1> | <2> | <1.2> | <1.8> | |||||||
Fibrous thickening, interstitial | 0 | 0 | 0 | 6** | 8*** | 0 | 0 | 0 | 6** | 8*** |
<1> | <1> | <1> | <1.5> | |||||||
Accumulation of lipoproteinous material, air space | 0 | 0 | 0 | 0 | 8*** | 0 | 0 | 0 | 0 | 7*** |
<1> | <1.4> |