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Table 2 Incidence of proliferative and neoplastic lesions at 52 weeks

From: Assessment of the toxicity and carcinogenicity of double-walled carbon nanotubes in the rat lung after intratracheal instillation: a two-year study

 

Untreated

Vehicle

DWCNT

0.125 mg/rat

DWCNT

0.250 mg/rat

DWCNT

0.500 mg/rat

MWCNT

0.500 mg/rat

Number of rats examined

5

5

5

7

6

5

Bronchiolo-alveolar Hyperplasia (BAH)

0

0

2

5*,#

5*,#

1

Pleural Mesothelioma

0

0

0

0

0

1

  1. *Difference from Vehicle group: p < 0.05
  2. #Difference from MWCNT-7 group: p < 0.05
  3. No lung tumors were found in any of the rats sacrificed at 52 wk