Table 4 Cell proliferation and inflammation related parameters in the lung tissue at 52 weeks

Granulation tissue

count/cm² mean ± S.D

1.1 ± 0.35

2.4 ± 1.2

98.8 ± 31.0***

189 ± 32.5***^,#

404.4 ± 88.8***^,#

65.4 ± 11.8**

Macrophage count/cm² mean ± S.D

1.45 ± 0.23

6.93 ± 1.47

21.72 ± 4.2***

33.01 + 6.4***^,#

49.1 + 5.79***^,#

15.88 ± 5.79**

Alveolar cell

PCNA index %

10.77 ± 3.00

18.10 ± 8.65

16.51 ± 7.85

17.81 ± 7.40

25.85 ± 4.74

44.52 ± 7.55 **

CCL2 pg/mg lung protein mean ± S.D

3.30 ± 0.28

3.65 ± 0.44

16.69 ± 4.65***

23.36 + 4.33***^,#

22.37 + 3.7***^,#

9.49 ± 0.98***

CCL3 pg/mg lung protein mean ± S.D

6.82 ± 0.56

8.19 ± 0.73

40.32 ± 10.4**

69.09 + 7.84***^,#

135.57 + 11***^,##

24.86 ± 8.4*