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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: TFEB-lysosome pathway activation is associated with different cell death responses to carbon quantum dots in Kupffer cells and hepatocytes

Fig. 6

CD-induced TFEB nuclear translocation may be involved in lysosomal stress regulation. A Nuclear translocation of TFEB in KUP5 and AML12 cells after 0, 1, and 3 h were treated with 400 μg/mL CDs. KUP5 cells were observed by immunofluorescence and AML12 cells by mCherry-TFEB transfection. B–D TFEB expression in the nucleus and cytoplasm of KUP5 and AML12 cells treated with 400 μg/mL CDs for 3 h. E–H p-mTOR and p-ERK expression in KUP5 and AML12 cells after treatment with DMEM and 100 μg/mL CDs for 0, 3, 6, and 12 h. N = 3 replications. All values are mean ± SD. The statistical significance of differences was evaluated by one-way ANOVA. Compared with the control group. *, P < 0.05

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