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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: TFEB-lysosome pathway activation is associated with different cell death responses to carbon quantum dots in Kupffer cells and hepatocytes

Fig. 7

Graphical abstract. CDs leads to the production of ROS in both liver cells and autophagy activation by activating the TFEB-lysosome pathway. Of note, CDs can induce the accumulation of autophagosomes in KUP5 cells, leading to the arrest of autophagic flux and ultimately promoting cell apoptosis. Autophagic flux was unobstructed in AML12 cells, and the apoptosis level was not related to the progress of autophagic flux

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Particle and Fibre Toxicology

ISSN: 1743-8977

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