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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment

Fig. 1

A generic IATA as used in the GRACIOUS Framework to test grouping hypotheses and thereby support grouping of NFs. The blue boxes are the decision nodes which provide the questions to be addressed to streamline the information gathering. Each decision node is supported by a tiered testing strategy consisting of standard operating procedures (SOPs) where possible. Answering all of the decision nodes ‘yes’ results in moving down through the decision tree and acceptance of the hypothesis. If any of the answers is “no” this results in rejection of the grouping hypothesis and exiting the decision tree to the right. The tiered testing strategy described in this short communication would support one decision node in such an IATA

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