Table 1 Survival period, body weights, and lung weights in rats at week 104

Number of animals examined

30

29

28

Survival animal number (rate; %)

25 (83.3)

22 (75.9)

12 (41.4)

Average survival time (weeks)

99.7

96.5

92.8

Body weight (g)

417.9 ± 34

399.1 ± 30

384.6 ± 17*

Absolute lung weight (g)

1.32 ± 0.08

1.92 ± 0.1*

2.91 ± 0.3*

Relative lung weight (g/100 g body weight)

0.31 ± 0.03

0.48 ± 0.05*

0.76 ± 0.06*