Fig. 7
From: Impact of in vitro digested zinc oxide nanoparticles on intestinal model systems
Basolateral FITC-dextran concentrations of Caco-2 monocultured (a) and Caco-2/HT29-MTX cocultured cells (b) after 24 h of treatment with digested ZnO NP (< 50 nm and < 100 nm) and ZnCl2. FITC-dextran was added in the apical compartment after cell incubation, and the basolateral was measured after 0.5 h (white bars), 1 h (grey bars), and 6 h (black bars). UC: untreated control; SC: solvent control (10% intestinal juice); PC: positive control (0.1% triton X-100 + 10 mM EGTA apical, 10 mM EGTA basolateral). Data are expressed as mean + SD; n = 4. Significant differences compared to UC (*P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001) were obtained by using the unpaired t test