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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Aryl hydrocarbon receptor activation-mediated vascular toxicity of ambient fine particulate matter: contribution of polycyclic aromatic hydrocarbons and osteopontin as a biomarker

Fig. 6

PM2.5-induced vascular remodeling, pulmonary inflammation, and IL-6 and OPN secretion was reduced in mice with low AhR affinity. The B6 and B6.D2 mice were aspirated with 25 μg of PM2.5 twice weekly for 12 weeks. A neutrophil numbers, B OPN protein in BALF, C IL-6 protein in BALF, and D OPN protein concentrations in plasma were determined. E Lung sections were stained with H&E. The arrow indicates the lesions of vascular remodeling. Scale bar, 200 μm. F The B6 mice was aspirated with 25 μg of PM2.5 twice weekly for 12 weeks. H&E; SMA staining; IHC staining of OPN; and IHC staining of IL-6. Arrows indicate small arteries. Scale bar, 30 μm. Each value represents the mean ± SD of ten mice. *P < 0.05 for comparison with the control-treated mice (n = 10, one-way ANOVA); #P < 0.05 for comparison between B6 and B6.D2 mice (n = 10, two-way ANOVA)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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