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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: The importance of mineralogical composition for the cytotoxic and pro-inflammatory effects of mineral dust

Fig. 3

© assay. Results are presented as mean ± SD (n = 4–5). Area under the curve (AUC) values in C and D were calculated from the values in A and B for the concentration-range of 0–400 µg/mL. All values were normalized to account for differences in baseline before calculating the AUC values by dividing each value by its respective control. Statistical significance is based on a two-way ANOVA followed by Dunnet’s post-test (A and B) or a one-way ANOVA followed by Tukey post-test (C and D). Asterisks (*) indicate statistically significant difference from the respective control (A and B), while a capped line indicates statistically significant difference between samples (C and D)

Mineral particles induce sample- and concentration-dependent decreases in cell viability. HBEC3-KT (A and C), THP-1 macrophages (B and D) were exposed to 0–400 µg/mL Na-feldspar, K-feldspar, Ca-feldspar, biotite, epidote, hornblende, actinolite, augite, quartz and orthopyroxene for 24 h. Cell viability was determined by alamarBlue

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