Fig. 9

The association between mineralogical composition and particle-induced cytokine release in THP-1 macrophages. The association between the content of individual mineral components and particle-induced release of CXCL8, IL-1β and TNFα was assessed using weighted linear regression (blues lines and symbol) and LASSO penalized regression (red symbol). Effect estimates represent percent change in the dependent variable for one unit increase in the independent variable. p values < 0.05 was considered statistically significant for the weighted linear regression, while all parameters present in the LASSO penalized model were considered statistically significant. All p values were corrected for multiple testing using Bonferroni correction. ***p < 0.001, **p < 0.01, *p < 0.05