| Deposition in distal lung | Does the NF dissolve very slowly in lung lining fluid/lysosomal? | Is HARN length > 5 µm? | Is the HARN rigid and maintain a fibrous, needle-like morphology? | Does the NF cause frustrated phagocytosis? | IATA outcome | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Tier 1 | Tier 2 | Tier 3 | Tier 1 | Tier 2 | Tier 3 | Tier 1 | Tier 2 | Tier 1 | Tier 2 | Tier 3 | Tier 1 | Tier 2 | Tier 3 |  |
NM-401 | Uncertain | Yes | Yes | Yes (predicted) | No data | Yes | No data | Yes | Yes | No data | Yes | Yes | No data | Yes | Accept grouping hypothesis |
NRCWE006 | Uncertain | Yes | Yes | Yes (predicted) | No data | Yes | Yes | Yes | Yes | No data | Yes | Yes | Yes | Yes | Accept grouping hypothesis |