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Table 6 IATA outcome for NM-401 and NRCWE006 after integration of additional decision node information gathered from targeted literature search

From: Grouping MWCNTs based on their similar potential to cause pulmonary hazard after inhalation: a case-study

  Deposition in distal lung Does the NF dissolve very slowly in lung lining fluid/lysosomal? Is HARN length > 5 µm? Is the HARN rigid and maintain a fibrous, needle-like morphology? Does the NF cause frustrated phagocytosis? IATA outcome
  Tier 1 Tier 2 Tier 3 Tier 1 Tier 2 Tier 3 Tier 1 Tier 2 Tier 1 Tier 2 Tier 3 Tier 1 Tier 2 Tier 3  
NM-401 Uncertain Yes Yes Yes (predicted) No data Yes No data Yes Yes No data Yes Yes No data Yes Accept grouping hypothesis
NRCWE006 Uncertain Yes Yes Yes (predicted) No data Yes Yes Yes Yes No data Yes Yes Yes Yes Accept grouping hypothesis