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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Development of a multi-route physiologically based pharmacokinetic (PBPK) model for nanomaterials: a comparison between a traditional versus a new route-specific approach using gold nanoparticles in rats

Fig. 4

The probabilistic time-course predictions [median (black-dashed line) and 95% confidence interval (CI) (color shadows)] from the nano-iPBPK model calibration results compared with pharmacokinetic data in rats after intravenous injection (IV), oral administration (Oral), intratracheal instillation (IT) of 18 nm AuNPs and endotracheally inhaled (IH) exposure of 23 nm AuNPs. Symbols and error bars (mean ± SD) represent measured amounts and dashed lines represent simulated amounts of AuNPs (percent of the initial dose [%ID] or initial peripheral lung dose [%IPLD]) in blood, lungs, liver, kidneys, spleen, remaining tissues. The read-dashed lines represent the simulation results from the PBPK model derived using the traditional route-to-route extrapolation approach

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