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Fig. 8 | Particle and Fibre Toxicology

Fig. 8

From: Titanium dioxide and carbon black nanoparticles disrupt neuronal homeostasis via excessive activation of cellular prion protein signaling

Fig. 8

TiO2 nanoparticles trigger TNFR1 accumulation in vivo. a TNFR1 immunostaining on two representative brain sections from non-injected, sham-operated, and mice exposed to 10 µg of TiO2-NPs delivered by an unilateral intra-cerebro-ventricular (ICV) injection 8 weeks before. TNFR1 was detected in the cortex (Cx), septum (Sp) striatum (St), hippocampus (Hip), thalamic (Th) nuclei, and substantia nigra (SN). b Higher magnification of the subicular cortex shows TNFR1 rise at the plasma membrane of neurons that is stronger in TiO2-NPs-injected mice than in sham-operated mice (arrows). Scale bar = 25 µm

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Particle and Fibre Toxicology

ISSN: 1743-8977

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