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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Macrophage-mediated tissue response evoked by subchronic inhalation of lead oxide nanoparticles is associated with the alteration of phospholipases C and cholesterol transporters

Fig. 1

Characterization of PbO NPs. A Particle number-size distribution of PbO NPs in the inhalation chambers measured by Scanning Mobility Particle Sizer (SMPS). B STEM image of PbO NPs. C Design of the inhalation experiment. Symbols of light circle indicate clean air, and symbols of dark circles indicate PbO NPs. D Surface area of PbO NP size distribution (dS/dlogDp) calculated according to the ICRP deposition model. The surface area of fractions of PbO NPs deposited in the extrathoracic (SET), tracheobronchiolar (STB) and alveolar region (SA) of lungs, ST—the total surface area of generated PbO NPs, STB+A—the lung-deposited surface area. E Analysis of Pb concentration (ng/g) in organs following 11 weeks of PbO NP inhalation. Limit of detection in the lung, liver, kidney, and spleen was 75, 13, 84, and 117 ng/g Pb, respectively. The graphs values denote average ± SD; *p < 0.05; ***p < 0.001 by unpaired t-test

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Particle and Fibre Toxicology

ISSN: 1743-8977

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