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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Enhanced silver nanoparticle-induced pulmonary inflammation in a metabolic syndrome mouse model and resolvin D1 treatment

Fig. 6

Chronic effect of AgNP exposure and modulation by RvD1 treatment on pulmonary gene expression associated with lipid metabolism including A Arachidonate 5-lipoxygenase (ALOX-5), B arachidonate 15-lipoxygenase (ALOX-15), C inducible nitric oxide synthase (iNOS), and D phospholipase A2 (iPLA2) from healthy and MetS mice. 24 h following oropharyngeal aspiration of pharmaceutical grade sterile water (control) or AgNPs (50 µg) in sterile water, mice were oropharyngeal aspiration with 400 ng RvD1 or sterile saline (vehicle). Endpoints were evaluated at 3-, 7-, 14- and 21-days post AgNP exposures. Values are expressed as mean ± S.E.M. * AgNP exposure; # disease model; $ treatment; and t time point (p < 0.05)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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