Table 1 Summary of Changes in Response to Fe Only or to Combined Fe + SO2
| Â | Females | Males | ||
|---|---|---|---|---|
| Â | Fe | Fe + SO2 | Fe | Fe + SO2 |
Body weight |  | ↓ |  |  |
Lung metal | ↓P | ↓Mn | ↑Ca, Na | ↑Fe |
Olfactory Bulb matals | ↑Zn | ↓K |  |  |
Frontal cortex metals | ↓Mg, K, Ca, P, S, Cu, Zn |  |  | ↑Mg, K, Zn |
Lung Fe correlations | Na | Mg, P | Zn | Â |
Olfactory bulb Fe correlations | Ca, S, Se | Na, K, S, Mn, SE | Mg, P, Mn | Na, K, S, Mn, Se |
Frontal cortex Fe correlations | Mn | Mg, K, P, Zn, Se | K, Ca, Zn | Na, Mg, K, P, S, Cu |
Lung Fe correlations | Na, Mg, Ca, Cu, Mn | Mg, K, P, Zn, Se | Na, Cu, Mn | Na, Mg, K, Zn |
Olfactory bulb S correlations | Na, Mg, K, P, Fe, Zn, Mn, Se | Cu, Mn | P, Fe, Se | P, Zn, Mn |
Frontal cortex S correlations | Ca, Zn | ↓Mg, K, P, Cu, Zn, Se | Na, K, Mn, Se | Na, Mg, K, P, Fe, Cu |
Frontal cortex Glutamatergic PND14 | ↑Gln/Glu | ↓Glu |  |  ~ ↑Gln, ↑Glu, GABA |
Frontal cortex Serotonergic PND14 |  | ↓5HTP | ↓5HIAA | ↑Trp |
Frontal cortex Dopaminergic PND14 | ↑HVA/DA, DOPAC/DA |  ~ ↓NE |  |  ~ ↑DA |
Striatal Glutamatergic PND14 |  | ↓Gln, Glu, GABA, Gln/Glu, Glu/GABA |  |  ~ ↑Glu, ↑Glu/ GABA |
Striatal Serotonergic PND14 |  | ↓SHIAA/SHT |  | ↓5HIAA, 5HT |
Striatal Dopaminergic PND14 | ↑Tyr |  ~ ↓Tyr, ↓HVA, DOPAC, DA, D |  | ↑HVA, DOPADA, DA/Tyr, ↓NE |
Frontal Cortex Trans-Sulfuration PND14 |  | ↓H-Cys, ~ ↑Cys |  ~ ↑Cys | ↑Met, ~ ↑H-Cys |
Serum Glutathione |  |  ~ ↑ |  |  |
Serum IL1a |  | ↑ |  |  |
Lateral Ventricle area | ↑ | ↓ |  |  |
Lateral Ventricle perimeter | ↑ | ↑ |  |  |