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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Chronic maternal exposure to titanium dioxide nanoparticles alters breathing in newborn offspring

Fig. 6

Effect of temperature on burst frequency of the respiratory CPG in unexposed and prenatally TiO2 NP-exposed neonates. A Schematic of experimental procedure. B Raw extracellular burst activity recorded from a C4 ventral root in isolated preparations from unexposed (Control, green traces) and prenatally TiO2 NP (200 µg/g)-exposed (purple traces) neonates under standard (24 °C, upper traces) and elevated (29 °C, lower traces) bath temperatures. C Bar charts showing changes in spontaneous respiratory burst frequency as a function of time (mean ± SEM) in control (green bars) and prenatally TiO2 NP-exposed (purple bars) groups under the warming protocol. Data were pooled from P0 to P3. *p < 0.05; ns, not statistically significant

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