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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Amine-modified nanoplastics promote the procoagulant activation of isolated human red blood cells and thrombus formation in rats

Fig. 6

Effects of PS-NPs on rat RBCs in vitro and rat venous thrombosis model in vivo. A Freshly isolated rat RBCs were treated with various concentrations of PS-NPs for 3 h. Hemolysis (n = 6), PS exposure (n = 4), and thrombin generation (n = 6) were measured as described in the methods. B Three hours after intravenous injection of saline (control) or PS-NPs (0.25, 0.5, or 1 mg/kg), thrombus formation was induced by the infusion of thromboplastin in a rat venous thrombosis model. We showed the different sizes of thrombus from a rat vein (n = 4–8). Data are presented as the mean ± SE. *p < 0.05, **p < 0.01, ***p < 0.001 versus control (CON)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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