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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Amine-modified nanoplastics promote the procoagulant activation of isolated human red blood cells and thrombus formation in rats

Fig. 7

Scheme for the effect of PS-NPs on the procoagulant activity of RBCs contributing to thrombosis. PS-NPs entering the body are exposed to RBC during circulation. PS-NPs are attached to the RBC surface and induce morphological change. Changes in the intracellular environment, such as increased levels of intracellular calcium and decreased levels of glutathione and ATP, are observed in exposed RBCs, resulting in increased scramblase activity. These alterations on RBCs lead to increased phosphatidylserine (PS) exposure and microvesicle (MV) formation by PS-NPs. PS-NPs affect the adhesion of RBC to endothelial cells (EC) and promote procoagulant activity, increasing thrombus formation in blood vessels

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Particle and Fibre Toxicology

ISSN: 1743-8977

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