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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Lung recovery from DNA damage induced by graphene oxide is dependent on size, dose and inflammation profile

Fig. 1

Experimental design of the study. Single (high-dose) and repeated (low and high-dose) exposure to nanometric (USGO) or micrometric (LGO) graphene oxide sheets or MWCNTs were delivered to mouse lungs by oro-pharyngeal aspiration. Quantification of DNA damages in formalin-fixed paraffin embedded lung sections was performed using recombinant rabbit anti-mouse γ-H2Ax-Phosphorilated Ser139, combined with anti-mouse CD45 Alexa Fluor 594 and anti-mouse E-Cadherin Alexa Fluor 488 to phenotype the damaged cells (n = 3). A correlation matrix was performed for the repeated exposure (high-dose) study using inflammation parameters obtained from BALF, whole lung ELISA, and RT-qPCR obtained from the same animals (n = 6). Figure created with BioRender.com

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Particle and Fibre Toxicology

ISSN: 1743-8977

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