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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress

Fig. 1

PM2.5 exposure affects the ADMA/DDAH pathway. A Experimental schema for chronic PM2.5 exposure is illustrated in diagram. The mean monthly PM2.5 concentrations from July to December 2017 are shown. B Mice were placed in the PM2.5 exposure system. After exposure to PM2.5 for 3 or 6 months, their serum ADMA levels were measured. Mice placed in the chamber with filtered air (FA) for 6 months were used as control. C The protein expression of dimethylarginine dimethylaminohydrolase 1 (DDAH1), DDAH2 and protein arginine methyltransferase 1 (PRMT1) in lung lysates were examined by Western blots. D Experimental schema for acute PM2.5 exposure is illustrated in diagram. E C57BL/6 mice were exposed to PM2.5 (10 mg/kg) every other day via intratracheal instillation as the indicated times, and then their serum ADMA levels were measured. Mice treated with PBS for 8 weeks were used as control. F Lysates of the lung tissue were examined by Western blots. In Fig. B and E, N = 5; in Fig. C, N = 3; in Fig. F, N = 4; Data are presented as the mean ± SD; *indicates p < 0.05, **indicates p < 0.01

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