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Table 4 Summary of the AOP of neurologic system

From: A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence

Sequence

Type

Event ID

Title

Short name

1

MIE

1115

ROS generation

Increased, Reactive oxygen species

2

MIE

151

Inflammatory pathways Activation

Inflammatory pathways Activation

3

KE

1392

Oxidative stress

Oxidative stress

4

KE

1239

Altered gene expression

Altered, Gene Expression

5

KE

191

Neuronal dysfunction

Neuronal dysfunction

6

KE

149

Inflammatory response

Increase, Inflammation

7

KE

1496

Secretion of inflammatory factors

Increased proinflammatory mediators

8

KE

1998

Microglia activation

Microglia activation

9

KE

1514

Neurodegeneration

Neurodegeneration

10

KE

188

Neuroinflammation

Neuroinflammation

11

AO

1999

Neurodegenerative disease

Neurodegenerative disease

12

AO

402

Decreased cognitive Function

Cognitive Function, Decreased

  1. MIE molecular initiating events, KE key events, AO adverse outcomes