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Table 1 The DNs (green) (with relative biological endpoints) of the oral Integrated Approach to Testing and Assessment (IATA), and the tiered testing strategy (TTS) (blue) to support collection of evidence for grouping (Table adapted from [6] (© MDPI, 2021)

From: Grouping of orally ingested silica nanomaterials via use of an integrated approach to testing and assessment to streamline risk assessment

  1. The red stars indicate the DNs addressed in this study. The bold text at Tier 1 and Tier 2 level indicates the assays performed to complete the data matrix required for the similarity assessment. The bold text at Tier 3 indicates the questions addressed by literature-based evidence
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Particle and Fibre Toxicology

ISSN: 1743-8977

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