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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review

Fig. 4

Putative AOP (pAOP) on Ag NPs reproductive toxicity relations with already existing AOPs, AOP18 [138] PPARα activation in utero leading to impaired fertility in males, AOP64 [151] Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility, AOP207 [55] NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans

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Particle and Fibre Toxicology

ISSN: 1743-8977

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