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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Establishing relationships between particle-induced in vitro and in vivo inflammation endpoints to better extrapolate between in vitro markers and in vivo fibrosis

Fig. 1

Schematic of AOP 173. AOP 173, “Substance interaction with the lung resident cell membrane components leading to lung fibrosis” adapted from [20]. Green box identifies the molecular initiating event (MIE), grey boxes are key events (KEs) and red boxes show adverse outcomes (AO). Yellow stars identify the focus of our in vivo literature search and the blue star identifies the KE of importance for our in vitro literature search

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