Establishing relationships between particle-induced in vitro and in vivo inflammation endpoints to better extrapolate between in vitro markers and in vivo fibrosis

Table 4 BMD results for α-quartz in vivo PMN influx and selected in vitro endpoints

Study	Model	Endpoint	COV in controls (%)	BMR (%)	BMDL (cm²/cm²)	BMDU (cm²/cm²)	Magnitude change [log10(BMDU) – log10(BMDL)]
in vivo IVIVE	Rat	PMN	n.d.—92.62	100	0.041	0.0605	0.169
Nattrass et al. [51]	Submerged: J774	TNF-α	n.d	20	0.176	1.05	0.776
				50	0.449	1.37	0.484
				100	0.781	1.71	0.340
Boyles et al. [50]	Submerged: J774A1	TNF-α	8.33	20	0.091	0.216	0.375
				50	0.194	0.365	0.274
				100	0.344	0.531	0.189

n.d. = not determined, typically due to very low error in graphs therefore no distinction between average and error bar using software

ISSN: 1743-8977