Establishing relationships between particle-induced in vitro and in vivo inflammation endpoints to better extrapolate between in vitro markers and in vivo fibrosis

Table 6 EC50 values for nano-CeO₂ in vivo PMN influx and in vitro inflammatory endpoints

Dose — cm²/cm²	IL-6 in vitro		in vivo
log(agonist) vs. normalized response—Variable slope	Kim et al. [58], MH-S, 24 h, CeO₂ (23)	Kim et al. [58], MH-S, 24 h, CeO₂ (88)	PAR = 300 cm²
Best-fit value, EC50	3.452	0.7873	0.4742
95% CI, EC50	3.105 to 3.830	0.7039 to 0.8788	0.3648 to 0.6544
Best-fit value, HillSlope	2.101	2.055	1.242

The in vitro inflammatory endpoints included in the table all showed overlap with in vivo PMN influx

ISSN: 1743-8977