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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation

Fig. 1

Microglial activation induced by intranasal administration of CRM28. CRM28 was suspended in water and intranasally (i.n.) administered at doses of 0, 10 or 100 µg/mouse once a day for 7 days. Brain slices were stained with Iba1 and CD68 and observed by confocal microscopy. A Representative stained pictures of the olfactory bulb. B Amoeboid scores. C The CD68-stained area of the olfactory bulb. The values are presented as the mean ± S.D. (n = 6 animals in each group). The data were analyzed using one-way ANOVA [B F(2, 15) = 4.524, p = 0.0290, C F(2, 15) = 6.770, p = 0.0080] followed by Dunnett’s multiple comparisons test. D Representative stained pictures of the cerebral cortex. E Amoeboid scores. F The CD68-stained area of the cerebral cortex. The values are presented as the mean ± S.D. (n = 6 animals in each group). The data were analyzed using one-way ANOVA [E: F(2, 15) = 9.860, p = 0.0018, F: F(2, 15) = 21.83, p < 0.0001] followed by Dunnett’s multiple comparisons test

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