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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation

Fig. 4

Enhancement of brain edema after ischemic stroke by CRM28 exposure. CRM28 was suspended in water and intranasally (i.n.) administered at doses of 0, 10 or 100 µg/mouse once a day for 7 days. One day after induction of photothrombosis, T1WI and T2WI were obtained for each mouse by MRI, and then the infarct area was determined by TTC staining. A Representative images of T1WI, T2WI and TTC staining. B T2 hyperintense lesion (T2WI), TTC-unstained area (Infarct) and edema region (T2 hyperintense lesion except infarct) were quantified by ImageJ software. The values are presented as the mean ± S.D. (n = 5 animals in each group). The data were analyzed using one-way ANOVA [T2WI F(2, 12) = 9.124, p = 0.0039, Infarct F(2, 12) = 1.708, p = 0.2225, Edema F(2, 12) = 4.893, p = 0.0279] followed by Dunnett’s multiple comparisons test

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Particle and Fibre Toxicology

ISSN: 1743-8977

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