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Fig. 10 | Particle and Fibre Toxicology

Fig. 10

From: Derivation of first-order dissolution rates to estimate particle clearance and burden in the human respiratory tract

Fig. 10

Total dissolution (includes all lung regions and the gastrointestinal tract) available for absorption into blood. Mn-laden aerosol (concentration = 100 µg-Mn/m3) of indicated sized particles (density = 5.08 g/cm3) were inhaled while a light exercise level of activity for 8-h/day, 5 days/week, for 3 years by adult male exposed by welding. The 5 days/week exposure was implemented by reducing the daily amount of air inhaled by 5/7 to smooth the illustrated lines. The Mn form from welding was assumed to be MnO2, the MnSO4 line illustrates the daily dissolution rate of a highly soluble Mn form. The daily dissolution includes gastrointestinal absorption of 5% for MnSO4 and 0.05% for MnO2

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