Fig. 9From: Derivation of first-order dissolution rates to estimate particle clearance and burden in the human respiratory tractTotal dissolution (includes all lung regions and the gastrointestinal tract) of particles normalized to amount of material inhaled. Monodisperse aerosol (concentration = 1.0 µg/m3) of indicated sized particles (density = 3 g/cm3) were inhaled for 8-h/day for 3 years by adult male exposed while sitting at rest. The daily dissolution reflects that occurring on day 1095 of exposure with gastrointestinal absorption of 10%Back to article page