Derivation of first-order dissolution rates to estimate particle clearance and burden in the human respiratory tract

Table 5 Particle deposition fraction and dose rates in regions of adult respiratory tract following inhalation of polydisperse aerosols (GSD = 2.0)

Activity	Region	Sex	Inhaled mass median diameter (µm)^a
			0.1	0.5	1	5	10
			Deposition fraction (Dose rate, µg/day)^b
Sitting	ET	Male	0.04 (0.02)	0.11 (0.06)	0.22 (0.12)	0.62 (0.33)	0.62 (0.33)
		Female	0.05 (0.02)	0.12 (0.04)	0.25 (0.10)	0.65 (0.25)	0.62 (0.24)
	TB	Male	0.12 (0.07)	0.07 (0.04)	0.09 (0.05)	0.12 (0.07)	0.08 (0.05)
		Female	0.13 (0.05)	0.07 (0.03)	0.09 (0.03)	0.11 (0.04)	0.07 (0.03)
	PU	Male	0.21 (0.11)	0.16 (0.08)	0.20 (0.11)	0.10 (0.05)	0.03 (0.02)
		Female	0.17 (0.07)	0.12 (0.05)	0.15 (0.06)	0.07 (0.03)	0.02 (0.01)
Light exercise	ET	Male	0.03 (0.05)	0.11 (0.16)	0.22 (0.33)	0.62 (0.92)	0.67 (0.99)
		Female	0.03 (0.04)	0.10 (0.13)	0.22 (0.27)	0.61 (0.76)	0.66 (0.82)
	TB	Male	0.10 (0.15)	0.06 (0.09)	0.07 (0.10)	0.11 (0.17)	0.08 (0.11)
		Female	0.10 (0.13)	0.06 (0.07)	0.07 (0.09)	0.12 (0.15)	0.08 (0.10)
	PU	Male	0.21 (0.31)	0.14 (0.20)	0.18 (0.27)	0.11 (0.16)	0.03 (0.05)
		Female	0.22 (0.27)	0.14 (0.17)	0.18 (0.23)	0.11 (0.14)	0.03 (0.04)
Heavy exercise	ET	Male	0.03 (0.09)	0.12 (0.36)	0.25 (0.73)	0.65 (2.0)	0.70 (2.1)
		Female	0.03 (0.08)	0.12 (0.32)	0.24 (0.66)	0.65 (1.8)	0.70 (1.9)
	TB	Male	0.09 (0.27)	0.06 (0.18)	0.08 (0.23)	0.13 (0.39)	0.07 (0.22)
		Female	0.09 (0.24)	0.06 (0.16)	0.08 (0.22)	0.14 (0.37)	0.08 (0.21)
	PU	Male	0.20 (0.58)	0.11 (0.34)	0.14 (0.42)	0.07 (0.20)	0.02 (0.05)
		Female	0.19 (0.50)	0.10 (0.28)	0.13 (0.34)	0.06 (0.15)	0.01 (0.03)

^aDeposition calculations are for a particle density of 3 g/cm³ in this example
^bDose rates are for an inhaled aerosol concentration containing 1 µg of the compound of interest per cubic meter

ISSN: 1743-8977