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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Human dendritic cell maturation induced by amorphous silica nanoparticles is Syk-dependent and triggered by lipid raft aggregation

Fig. 7

Lipid rafts are necessary to activate Syk in response to SAS-NPs. Immature moDCs were pre-treated for 1 h with Methyl-ß-cyclodextrin (MßCD, 5 mM) and then treated for 30 min with 25 µg.mL−1 SAS-NPs. A Representative experiment. B Immunoblotting of whole-cell extracts was used to quantify the phosphorylated form of Syk. The results of 3 independent experiments are represented. Bands were quantified using the Image Lab software. Results are expressed as the fold induction, representing the ratio of the normalised intensity of specific bands of treated cells divided by the normalised intensity of bands of untreated cells, ****p < 0.0001 One-way ANOVA and Bonferroni’s multiple comparison test

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Particle and Fibre Toxicology

ISSN: 1743-8977

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