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Fig. 8 | Particle and Fibre Toxicology

Fig. 8

From: Human dendritic cell maturation induced by amorphous silica nanoparticles is Syk-dependent and triggered by lipid raft aggregation

Fig. 8

Lipid raft aggregation following SAS-NP exposure leads to Src/Syk signalling pathway activation in human dendritic cells. Upon DC exposure to SAS-NPs, lipid raft aggregation leads to Src kinase recruitment required for the phosphorylation of the tyrosine kinase Syk. Syk phosphorylation is linked to JNK activation and DC maturation. p38 MAPK phosphorylation seems to be independent of Syk. Solid arrows: established links. Dashed arrows: hypotheses. The figure was partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license (https://creativecommons.org/licenses/by/3.0/)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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