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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Uncovering the Fate and Risks of Intravenously Injected Prussian Blue Nanoparticles in mice by an Integrated Methodology of Toxicology, Pharmacokinetics, Proteomics, and Metabolomics

Fig. 3

PK profile and degradation of PB NPs. (a) Changes in Fe content in the blood within 24 h after i.v. administration of 20 mg/kg PB NPs. (b) Changes in Fe content in major tissues at 24 h after i.v. administration of 20 mg/kg PB NPs. (c) The particle size of PB NPs with or without the protein corona. (d) Zeta potential of PB NPs with or without the protein corona. (e-i) The Fe content-time changes in the heart, lung, liver, spleen, and kidney after deducting the endogenous Fe content. (j) Changes in the color of PB NPs after incubation in SBF at pH 4.5 and pH 7.4. (k) and (l) Changes in the UV‒vis absorption of PB NPs after incubation in SBF at pH 4.5 and pH 7.4, respectively. (m) The XRD patterns and (n) FTIR spectra of PB NPs after incubation in SBFs at pH 7.4 and pH 4.5, respectively

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Particle and Fibre Toxicology

ISSN: 1743-8977

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