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  1. The exposure to pollutants such as diesel exhaust particles (DEP) is associated with an increased incidence of respiratory diseases. However, the mechanisms by which DEP have an effect on human health are not ...

    Authors: Solenne Taront, Audrey Dieudonné, Simon Blanchard, Pascale Jeannin, Philippe Lassalle, Yves Delneste and Philippe Gosset

    Citation: Particle and Fibre Toxicology 2009 6:9

    Content type: Research

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  2. Exposure to air pollution is an important risk factor for cardiovascular morbidity and mortality, and is associated with increased blood pressure, reduced heart rate variability, endothelial dysfunction and my...

    Authors: Jeremy P Langrish, Nicholas L Mills, Julian KK Chan, Daan LAC Leseman, Robert J Aitken, Paul HB Fokkens, Flemming R Cassee, Jing Li, Ken Donaldson, David E Newby and Lixin Jiang

    Citation: Particle and Fibre Toxicology 2009 6:8

    Content type: Research

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  3. Exposure to air pollution is associated with increased cardiovascular morbidity, although the underlying mechanisms are unclear. Vascular dysfunction reduces arterial compliance and increases central arterial ...

    Authors: Magnus Lundbäck, Nicholas L Mills, Andrew Lucking, Stefan Barath, Ken Donaldson, David E Newby, Thomas Sandström and Anders Blomberg

    Citation: Particle and Fibre Toxicology 2009 6:7

    Content type: Research

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  4. Individuals with chronic lung disease are at increased risk of adverse health effects from airborne particulate matter. Characterization of underlying pollutant-phenotype interactions may require comprehensive...

    Authors: Errol M Thomson, Andrew Williams, Carole L Yauk and Renaud Vincent

    Citation: Particle and Fibre Toxicology 2009 6:6

    Content type: Research

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  5. Exposure to small size particulate matter in urban air is regarded as a risk factor for cardiovascular effects, whereas there is little information about the impact on the cardiovascular system by exposure to ...

    Authors: Lise K Vesterdal, Janne K Folkmann, Nicklas R Jacobsen, Majid Sheykhzade, Håkan Wallin, Steffen Loft and Peter Møller

    Citation: Particle and Fibre Toxicology 2009 6:5

    Content type: Research

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  6. There is a need to better understand synergism in the biological effects of particles composed of multiple substances. The objective of this study was to determine if the oxidative stress in cultured cells cau...

    Authors: Bing Guo, Rema Zebda, Stephen J Drake and Christie M Sayes

    Citation: Particle and Fibre Toxicology 2009 6:4

    Content type: Research

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  7. Titanium dioxide (TiO2) nanoparticles and fullerene (C60) are two attractive manufactured nanoparticles with great promise in industrial and medical applications. However, little is known about the genotoxic resp...

    Authors: An Xu, Yunfei Chai, Takehiko Nohmi and Tom K Hei

    Citation: Particle and Fibre Toxicology 2009 6:3

    Content type: Research

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  8. The toxic and inflammatory potential of 5 different types of nanoparticles were studied in a sensitive model for pulmonary effects in apolipoprotein E knockout mice (ApoE-/-). We studied the effects instillation ...

    Authors: Nicklas Raun Jacobsen, Peter Møller, Keld Alstrup Jensen, Ulla Vogel, Ole Ladefoged, Steffen Loft and Håkan Wallin

    Citation: Particle and Fibre Toxicology 2009 6:2

    Content type: Research

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  9. Engineered iron nanoparticles are being explored for the development of biomedical applications and many other industry purposes. However, to date little is known concerning the precise mechanisms of transloca...

    Authors: Patrick L Apopa, Yong Qian, Rong Shao, Nancy Lan Guo, Diane Schwegler-Berry, Maricica Pacurari, Dale Porter, Xianglin Shi, Val Vallyathan, Vincent Castranova and Daniel C Flynn

    Citation: Particle and Fibre Toxicology 2009 6:1

    Content type: Research

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  10. The ability of nanoparticles to cross the lung-blood barrier suggests that they may translocate to blood and to targets distant from their portal of entry. Nevertheless, nanotoxicity in organs has received lit...

    Authors: Béatrice L'Azou, Joana Jorly, Dinhill On, Elisabeth Sellier, Frédéric Moisan, Jocelyne Fleury-Feith, Jean Cambar, Patrick Brochard and Céline Ohayon-Courtès

    Citation: Particle and Fibre Toxicology 2008 5:22

    Content type: Research

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  11. The extended session on Biological Evaluations with Carbon Nanotubes was held on 18 July, 2008 in Nagano as a part of the International Carbon 2008 Conference. During this session researchers and regulators di...

    Authors: Morinobu Endo, Shuji Tsuruoka and Gaku Ichihara

    Citation: Particle and Fibre Toxicology 2008 5:21

    Content type: Short report

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  12. Constituted only by carbon atoms, CNT are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies more complex.

    Authors: Dan Elgrabli, Magali Floriani, Steve Abella-Gallart, Laurent Meunier, Christelle Gamez, Patrice Delalain, Françoise Rogerieux, Jorge Boczkowski and Ghislaine Lacroix

    Citation: Particle and Fibre Toxicology 2008 5:20

    Content type: Research

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  13. Exposure to particulate matter is a risk factor for cardiopulmonary disease but the underlying molecular mechanisms remain poorly understood. In the present study we sought to investigate the cardiopulmonary r...

    Authors: Swapna Upadhyay, Tobias Stoeger, Volkar Harder, Ronald F Thomas, Mette C Schladweiler, Manuela Semmler-Behnke, Shinji Takenaka, Erwin Karg, Peter Reitmeir, Michael Bader, Andreas Stampfl, Urmila P Kodavanti and Holger Schulz

    Citation: Particle and Fibre Toxicology 2008 5:19

    Content type: Research

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  14. A novel methodology to detect unlabeled inorganic nanoparticles was experimentally demonstrated using a mixture of nano-sized (70 nm) and submicron (250 nm) silicon dioxide particles added to mammalian tissue....

    Authors: Cassandra E Deering, Soheyl Tadjiki, Shoeleh Assemi, Jan D Miller, Garold S Yost and John M Veranth

    Citation: Particle and Fibre Toxicology 2008 5:18

    Content type: Research

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  15. The production and use of nanoparticles is growing rapidly due to the unique physical and chemical properties associated with their nano size and large surface area. Since nanoparticles have unique physicochem...

    Authors: Tina M Sager, C Kommineni and Vincent Castranova

    Citation: Particle and Fibre Toxicology 2008 5:17

    Content type: Research

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  16. Inhalation of crystalline silica particles is in humans associated with inflammation and development of fibrosis. The aim of the present study was to investigate the effect of crystalline silica on the release...

    Authors: Jan I Herseth, Vivi Volden, Per E Schwarze, Marit Låg and Magne Refsnes

    Citation: Particle and Fibre Toxicology 2008 5:16

    Content type: Research

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  17. A newly designed electrostatic precipitator (ESP) in tandem with Versatile Aerosol Concentration Enrichment System (VACES) was developed by the University of Southern California to collect ambient aerosols on ...

    Authors: Zhi Ning, Markus Sillanpää, Payam Pakbin and Constantinos Sioutas

    Citation: Particle and Fibre Toxicology 2008 5:15

    Content type: Research

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  18. The aim of this study was to establish and validate a practical method to disperse nanoparticles in physiological solutions for biological in vitro and in vivo studies.

    Authors: Peter Bihari, Minnamari Vippola, Stephan Schultes, Marc Praetner, Alexander G Khandoga, Christoph A Reichel, Conrad Coester, Timo Tuomi, Markus Rehberg and Fritz Krombach

    Citation: Particle and Fibre Toxicology 2008 5:14

    Content type: Methodology

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  19. Particulate air pollution is associated with increased risk of cardiovascular events although the involved mechanisms are poorly understood. The objective of the present study was to investigate the effects of...

    Authors: Elvira V Bräuner, Peter Møller, Lars Barregard, Lars O Dragsted, Marianne Glasius, Peter Wåhlin, Peter Vinzents, Ole Raaschou-Nielsen and Steffen Loft

    Citation: Particle and Fibre Toxicology 2008 5:13

    Content type: Research

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  20. Welding fume has been categorized as "possibly carcinogenic" to humans. Our objectives were to characterize the lung response to carcinogenic and non-carcinogenic metal-containing welding fumes and to determin...

    Authors: Patti C Zeidler-Erdely, Michael L Kashon, Lori A Battelli, Shih-Houng Young, Aaron Erdely, Jenny R Roberts, Steven H Reynolds and James M Antonini

    Citation: Particle and Fibre Toxicology 2008 5:12

    Content type: Research

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  21. A recent publication in this journal reported interesting changes in electroencephalographic (EEG) waves that occurred in 10 young, male volunteers following inhalation for one hour of elevated levels of diese...

    Authors: Peter A Valberg, Christopher M Long and Thomas W Hesterberg

    Citation: Particle and Fibre Toxicology 2008 5:10

    Content type: Letter to the Editor

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  22. Epidemiological studies have demonstrated adverse health effects of environmental pollution. Diesel exhaust (DE) is a major contributor to particulate matter pollution. DE exposure has been shown to induce a p...

    Authors: Jamshid Pourazar, Anders Blomberg, Frank J Kelly, Donna E Davies, Susan J Wilson, Stephen T Holgate and Thomas Sandström

    Citation: Particle and Fibre Toxicology 2008 5:8

    Content type: Research

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  23. Exposure to air pollution particles has been acknowledged to be associated with excess generation of oxidative damage to DNA in experimental model systems and humans. The use of standard reference material (SR...

    Authors: Pernille Høgh Danielsen, Steffen Loft and Peter Møller

    Citation: Particle and Fibre Toxicology 2008 5:6

    Content type: Research

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  24. Ambient particulate matter and nanoparticles have been shown to translocate to the brain, and potentially influence the central nervous system. No data are available whether this may lead to functional changes...

    Authors: Björn Crüts, Ludo van Etten, Håkan Törnqvist, Anders Blomberg, Thomas Sandström, Nicholas L Mills and Paul JA Borm

    Citation: Particle and Fibre Toxicology 2008 5:4

    Content type: Short report

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  25. Results from epidemiological studies indicate that particulate air pollution constitutes a hazard for human health. Recent studies suggest that diesel exhaust possesses endocrine activity and therefore may aff...

    Authors: Karin S Hougaard, Keld A Jensen, Pernille Nordly, Camilla Taxvig, Ulla Vogel, Anne T Saber and Håkan Wallin

    Citation: Particle and Fibre Toxicology 2008 5:3

    Content type: Research

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  26. Reactive oxygen species including hydroxyl radicals can cause oxidative stress and mutations. Inhaled particulate matter can trigger formation of hydroxyl radicals, which have been implicated as one of the cau...

    Authors: Corey A Cohn, Sanford R Simon and Martin AA Schoonen

    Citation: Particle and Fibre Toxicology 2008 5:2

    Content type: Research

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  27. We have shown that pulmonary exposure to fine particulate matter (PM) impairs endothelium dependent dilation in systemic arterioles. Ultrafine PM has been suggested to be inherently more toxic by virtue of its...

    Authors: Timothy R Nurkiewicz, Dale W Porter, Ann F Hubbs, Jared L Cumpston, Bean T Chen, David G Frazer and Vincent Castranova

    Citation: Particle and Fibre Toxicology 2008 5:1

    Content type: Research

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  28. Nanotechnology is the new industrial revolution of the 21st Century as the various processes lead to radical improvements in medicine, manufacturing, energy production, land remediation, information technology...

    Authors: Barry Park, Patricia Martin, Chris Harris, Robert Guest, Andrew Whittingham, Peter Jenkinson and John Handley

    Citation: Particle and Fibre Toxicology 2007 4:12

    Content type: Research

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  29. Nanotechnology in its widest sense seeks to exploit the special biophysical and chemical properties of materials at the nanoscale. While the potential technological, diagnostic or therapeutic applications are ...

    Authors: Christian Mühlfeld, Barbara Rothen-Rutishauser, Dimitri Vanhecke, Fabian Blank, Peter Gehr and Matthias Ochs

    Citation: Particle and Fibre Toxicology 2007 4:11

    Content type: Review

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  30. The study aims at revealing the fate of nanoparticles administered intravenously and intraperitoneally to adult female mice, some of which were pregnant. Gold nanoparticles were chosen as a model because these...

    Authors: Evaldas Sadauskas, Håkan Wallin, Meredin Stoltenberg, Ulla Vogel, Peter Doering, Agnete Larsen and Gorm Danscher

    Citation: Particle and Fibre Toxicology 2007 4:10

    Content type: Research

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  31. Experimental studies provide evidence that inhaled nanoparticles may translocate over the airspace epithelium and cause increased cellular inflammation. Little is known, however, about the dependence of partic...

    Authors: Barbara Rothen-Rutishauser, Christian Mühlfeld, Fabian Blank, Claudia Musso and Peter Gehr

    Citation: Particle and Fibre Toxicology 2007 4:9

    Content type: Research

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  32. Pesticides, in particular folpet, have been found in rural and urban air in France in the past few years. Folpet is a contact fungicide and has been widely used for the past 50 years in vineyards in France. Sl...

    Authors: Mireille Canal-Raffin, Beatrice L'Azou, Beatrice Martinez, Elisabeth Sellier, Fawaz Fawaz, Philip Robinson, Celine Ohayon-Courtès, Isabelle Baldi, Jean Cambar, Mathieu Molimard, Nicholas Moore and Patrick Brochard

    Citation: Particle and Fibre Toxicology 2007 4:8

    Content type: Research

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  33. Translocation of nanoparticles (NP) from the pulmonary airways into other pulmonary compartments or the systemic circulation is controversially discussed in the literature. In a previous study it was shown tha...

    Authors: Christian Mühlfeld, Marianne Geiser, Nadine Kapp, Peter Gehr and Barbara Rothen-Rutishauser

    Citation: Particle and Fibre Toxicology 2007 4:7

    Content type: Research

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  34. Although the mechanisms of airborne particulate matter (PM) related health effects remain incompletely understood, one emerging hypothesis is that these adverse effects derive from oxidative stress, initiated ...

    Authors: Leonidas Ntziachristos, John R Froines, Arthur K Cho and Constantinos Sioutas

    Citation: Particle and Fibre Toxicology 2007 4:5

    Content type: Research

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  35. A symposium on the mechanisms of action of inhaled airborne particulate matter (PM), pathogenic particles and fibers such as silica and asbestos, and nanomaterials, defined as synthetic particles or fibers les...

    Authors: Brooke T Mossman, Paul J Borm, Vincent Castranova, Daniel L Costa, Kenneth Donaldson and Steven R Kleeberger

    Citation: Particle and Fibre Toxicology 2007 4:4

    Content type: Commentary

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  36. Accurate characterization of the physicochemical properties of aerosols generated for inhalation toxicology studies is essential for obtaining meaningful results. Great emphasis must also be placed on characte...

    Authors: Aleksandr B Stefaniak, Mark D Hoover, Robert M Dickerson, Gregory A Day, Patrick N Breysse and Ronald C Scripsick

    Citation: Particle and Fibre Toxicology 2007 4:3

    Content type: Short report

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  37. The induction of cytokines by airway cells in vitro has been widely used to assess the effects of ambient and occupational particles. This study measured cytotoxicity and the release of the proinflammatory cytoki...

    Authors: John M Veranth, Erin G Kaser, Martha M Veranth, Michael Koch and Garold S Yost

    Citation: Particle and Fibre Toxicology 2007 4:2

    Content type: Research

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  38. Epidemiological studies on health effects of air pollution have consistently shown adverse cardiovascular effects. Toxicological studies have provided evidence for thrombogenic effects of particles.

    Authors: Regina Rückerl, Richard P Phipps, Alexandra Schneider, Mark Frampton, Josef Cyrys, Günther Oberdörster, H Erich Wichmann and Annette Peters

    Citation: Particle and Fibre Toxicology 2007 4:1

    Content type: Research

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  39. The harmful effects from inhalation of coal dust are well-documented. The prevalence of lung disease varies by mining region and may, in part, be related to regional differences in the bioavailable iron conten...

    Authors: Corey A Cohn, Richard Laffers, Sanford R Simon, Thomas O'Riordan and Martin AA Schoonen

    Citation: Particle and Fibre Toxicology 2006 3:16

    Content type: Research

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  40. Nanotechnology is a rapidly advancing industry with many new products already available to the public. Therefore, it is essential to gain an understanding of the possible health risks associated with exposure ...

    Authors: James B Mangum, Elizabeth A Turpin, Aurita Antao-Menezes, Mark F Cesta, Edilberto Bermudez and James C Bonner

    Citation: Particle and Fibre Toxicology 2006 3:15

    Content type: Research

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  41. Although nitric oxide is overproduced by macrophages and neutrophils after exposure to silica, its role in silica-induced inflammatory reaction and apoptosis needs further clarification. In this study, rats we...

    Authors: He Wang and James Leigh

    Citation: Particle and Fibre Toxicology 2006 3:14

    Content type: Research

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  42. Particulate air pollution has been associated with respiratory and cardiovascular disease. Evidence for cardiovascular and neurodegenerative effects of ambient particles was reviewed as part of a workshop. The...

    Authors: Annette Peters, Bellina Veronesi, Lilian Calderón-Garcidueñas, Peter Gehr, Lung Chi Chen, Marianne Geiser, William Reed, Barbara Rothen-Rutishauser, Samuel Schürch and Holger Schulz

    Citation: Particle and Fibre Toxicology 2006 3:13

    Content type: Review

    Published on:

  43. Epidemiological studies have reported increased risks of cardiopulmonary-related hospitalization and death in association with exposure to elevated levels of particulate matter (PM) across a wide range of urba...

    Authors: Lindsay B Wichers, Allen D Ledbetter, John K McGee, Robert B Kellogg, William H Rowan III, Julianne P Nolan, Daniel L Costa and William P Watkinson

    Citation: Particle and Fibre Toxicology 2006 3:12

    Content type: Methodology

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  44. During the last few years, research on toxicologically relevant properties of engineered nanoparticles has increased tremendously. A number of international research projects and additional activities are ongo...

    Authors: Paul JA Borm, David Robbins, Stephan Haubold, Thomas Kuhlbusch, Heinz Fissan, Ken Donaldson, Roel Schins, Vicki Stone, Wolfgang Kreyling, Jurgen Lademann, Jean Krutmann, David Warheit and Eva Oberdorster

    Citation: Particle and Fibre Toxicology 2006 3:11

    Content type: Review

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  45. Particles are known to induce both cytokine release (MIP-2, TNF-α), a reduction in cell viability and an increased apoptosis in alveolar macrophages. To examine whether these responses are triggered by the sam...

    Authors: Magne Refsnes, Ragna B Hetland, Johan Øvrevik, Idunn Sundfør, Per E Schwarze and Marit Låg

    Citation: Particle and Fibre Toxicology 2006 3:10

    Content type: Research

    Published on:

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