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  1. Content type: Research

    Nanotechnology is a rapidly advancing industry with many new products already available to the public. Therefore, it is essential to gain an understanding of the possible health risks associated with exposure ...

    Authors: James B Mangum, Elizabeth A Turpin, Aurita Antao-Menezes, Mark F Cesta, Edilberto Bermudez and James C Bonner

    Citation: Particle and Fibre Toxicology 2006 3:15

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  2. Content type: Research

    Although nitric oxide is overproduced by macrophages and neutrophils after exposure to silica, its role in silica-induced inflammatory reaction and apoptosis needs further clarification. In this study, rats we...

    Authors: He Wang and James Leigh

    Citation: Particle and Fibre Toxicology 2006 3:14

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  3. Content type: Review

    Particulate air pollution has been associated with respiratory and cardiovascular disease. Evidence for cardiovascular and neurodegenerative effects of ambient particles was reviewed as part of a workshop. The...

    Authors: Annette Peters, Bellina Veronesi, Lilian Calderón-Garcidueñas, Peter Gehr, Lung Chi Chen, Marianne Geiser, William Reed, Barbara Rothen-Rutishauser, Samuel Schürch and Holger Schulz

    Citation: Particle and Fibre Toxicology 2006 3:13

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  4. Content type: Methodology

    Epidemiological studies have reported increased risks of cardiopulmonary-related hospitalization and death in association with exposure to elevated levels of particulate matter (PM) across a wide range of urba...

    Authors: Lindsay B Wichers, Allen D Ledbetter, John K McGee, Robert B Kellogg, William H Rowan III, Julianne P Nolan, Daniel L Costa and William P Watkinson

    Citation: Particle and Fibre Toxicology 2006 3:12

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  5. Content type: Review

    During the last few years, research on toxicologically relevant properties of engineered nanoparticles has increased tremendously. A number of international research projects and additional activities are ongo...

    Authors: Paul JA Borm, David Robbins, Stephan Haubold, Thomas Kuhlbusch, Heinz Fissan, Ken Donaldson, Roel Schins, Vicki Stone, Wolfgang Kreyling, Jurgen Lademann, Jean Krutmann, David Warheit and Eva Oberdorster

    Citation: Particle and Fibre Toxicology 2006 3:11

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  6. Content type: Research

    Particles are known to induce both cytokine release (MIP-2, TNF-α), a reduction in cell viability and an increased apoptosis in alveolar macrophages. To examine whether these responses are triggered by the sam...

    Authors: Magne Refsnes, Ragna B Hetland, Johan Øvrevik, Idunn Sundfør, Per E Schwarze and Marit Låg

    Citation: Particle and Fibre Toxicology 2006 3:10

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  7. Content type: Research

    Human β-defensin (hBD)-2, antimicrobial peptide primarily induced in epithelial cells, is a key factor in the innate immune response of the respiratory tract. Several studies showed increased defensin levels i...

    Authors: Hae Yun Nam, Eun-Kyung Ahn, Hyung Jung Kim, Young Lim, Chun Beoun Lee, Kyo Young Lee and Val Vallyathan

    Citation: Particle and Fibre Toxicology 2006 3:9

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  8. Content type: Research

    An Aerosol Time-of-Flight Mass Spectrometer (ATOFMS) was used to investigate the size and chemical composition of fine concentrated ambient particles (CAPs) in the size range 0.2–2.6 μm produced by a Versatile...

    Authors: Evelyn J Freney, Mathew R Heal, Robert J Donovan, Nicholas L Mills, Kenneth Donaldson, David E Newby, Paul HB Fokkens and Flemming R Cassee

    Citation: Particle and Fibre Toxicology 2006 3:8

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  9. Content type: Research

    Many epidemiological studies have shown that mass concentrations of ambient particulate matter (PM) are associated with adverse health effects in the human population. Since PM is still a very crude measure, t...

    Authors: Ingeborg M Kooter, A John F Boere, Paul HB Fokkens, Daan LAC Leseman, Jan AMA Dormans and Flemming R Cassee

    Citation: Particle and Fibre Toxicology 2006 3:7

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  10. Content type: Research

    Synthetic vitreous fibers (SVFs) are inorganic noncrystalline materials widely used in residential and industrial settings for insulation, filtration, and reinforcement purposes. SVFs conventionally include th...

    Authors: Patti C Zeidler-Erdely, William J Calhoun, Bill T Ameredes, Melissa P Clark, Gregory J Deye, Paul Baron, William Jones, Terri Blake and Vincent Castranova

    Citation: Particle and Fibre Toxicology 2006 3:5

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  11. Content type: Research

    Particulate air pollution has been associated with lung and cardiovascular disease, for which lung inflammation may be a driving mechanism. The pro-inflammatory cytokine, tumor necrosis factor (TNF) has been s...

    Authors: Anne T Saber, Nicklas R Jacobsen, Jette Bornholdt, Sanna L Kjær, Marianne Dybdahl, Lotte Risom, Steffen Loft, Ulla Vogel and Håkan Wallin

    Citation: Particle and Fibre Toxicology 2006 3:4

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  12. Content type: Research

    The aim of this study was to evaluate the acute lung toxicity in rats of intratracheally instilled TiO2 particles that have been substantially encapsulated with pyrogenically deposited, amorphous silica. Groups o...

    Authors: DB Warheit, TR Webb and KL Reed

    Citation: Particle and Fibre Toxicology 2006 3:3

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  13. Content type: Research

    Silicosis features foci of inflammation where macrophages and lymphocytes precede and accompany fibroblast proliferation, alveolar epithelial hyperplasia, and increased deposition of connective tissue matrix m...

    Authors: Gerald S Davis, Linda M Pfeiffer, David R Hemenway and Mercedes Rincon

    Citation: Particle and Fibre Toxicology 2006 3:2

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  14. Content type: Research

    Exposure to ambient particulate matter has been associated with a number of adverse health effects. Particle characteristics such as size, surface area and chemistry seem to influence the negative effects of p...

    Authors: Anette Kocbach, Yanjun Li, Karl E Yttri, Flemming R Cassee, Per E Schwarze and Ellen Namork

    Citation: Particle and Fibre Toxicology 2006 3:1

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  15. Content type: Research

    Alveolar macrophages are a key cell in dealing with particles deposited in the lungs and in determining the subsequent response to that particle exposure. Nanoparticles are considered a potential threat to the...

    Authors: Peter G Barlow, Anna Clouter-Baker, Ken Donaldson, Janis MacCallum and Vicki Stone

    Citation: Particle and Fibre Toxicology 2005 2:11

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  16. Content type: Review

    This review considers the molecular toxicology of combustion-derived nanoparticles (CDNP) following inhalation exposure. CDNP originate from a number of sources and in this review we consider diesel soot, weld...

    Authors: Ken Donaldson, Lang Tran, Luis Albert Jimenez, Rodger Duffin, David E Newby, Nicholas Mills, William MacNee and Vicki Stone

    Citation: Particle and Fibre Toxicology 2005 2:10

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  17. Content type: Review

    The rapid proliferation of many different engineered nanomaterials (defined as materials designed and produced to have structural features with at least one dimension of 100 nanometers or less) presents a dile...

    Authors: Günter Oberdörster, Andrew Maynard, Ken Donaldson, Vincent Castranova, Julie Fitzpatrick, Kevin Ausman, Janet Carter, Barbara Karn, Wolfgang Kreyling, David Lai, Stephen Olin, Nancy Monteiro-Riviere, David Warheit and Hong Yang

    Citation: Particle and Fibre Toxicology 2005 2:8

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  18. Content type: Research

    Asbestos is a known carcinogen and co-carcinogen. It is a persisting risk in our daily life due to its use in building material as asbestos-cement powder. The present study done on V79-cells (Chinese hamster l...

    Authors: Elke Dopp, Santosh Yadav, Furquan Ahmad Ansari, Kunal Bhattacharya, Ursula von Recklinghausen, Ursula Rauen, Klaus Rödelsperger, Behnaz Shokouhi, Stefan Geh and Qamar Rahman

    Citation: Particle and Fibre Toxicology 2005 2:9

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  19. Content type: Research

    Particulate air pollution is reported to cause adverse health effects in susceptible individuals. Since most of these particles are derived form combustion processes, the primary composition product is carbon ...

    Authors: Winfried Möller, David M Brown, Wolfgang G Kreyling and Vicki Stone

    Citation: Particle and Fibre Toxicology 2005 2:7

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  20. Content type: Research

    The burning of biomass in the developing world for heating and cooking results in high indoor particle concentrations. Long-term exposure to airborne particulate matter (PM) has been associated with increased ...

    Authors: Ian S Mudway, Sean T Duggan, Chandra Venkataraman, Gazala Habib, Frank J Kelly and Jonathan Grigg

    Citation: Particle and Fibre Toxicology 2005 2:6

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  21. Content type: Research

    Very high fibre inhalation exposure has been measured while people were wearing personal protective equipment manufactured from chrysotile asbestos. However, there is little data that relates specifically to w...

    Authors: John W Cherrie, Matthew Tindall and Hilary Cowie

    Citation: Particle and Fibre Toxicology 2005 2:5

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  22. Content type: Research

    Several studies have demonstrated an association between exposure to ambient particulate matter (PM) and respiratory and cardiovascular diseases. Inflammation seems to play an important role in the observed he...

    Authors: Ragna B Hetland, Flemming R Cassee, Marit Låg, Magne Refsnes, Erik Dybing and Per E Schwarze

    Citation: Particle and Fibre Toxicology 2005 2:4

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  23. Content type: Research

    Translocation of ultrafine particles (UFP) into the blood that returns from the lungs to the heart has been forwarded as a mechanism for particle-induced cardiovascular effects. The objective of this study was...

    Authors: James J Meiring, Paul JA Borm, Karim Bagate, Manuela Semmler, Jürgen Seitz, Shinji Takenaka and Wolfgang G Kreyling

    Citation: Particle and Fibre Toxicology 2005 2:3

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  24. Content type: Research

    It is estimated that over 80% of respirable particulate matter (PM10) in cities comes from road transport and that tire and brake wear are responsible for the 3–7% emission of it. Data on the indicators of enviro...

    Authors: Maurizio Gualtieri, Manuela Andrioletti, Paride Mantecca, Claudio Vismara and Marina Camatini

    Citation: Particle and Fibre Toxicology 2005 2:1

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  25. Content type: Research

    This study was performed within the scope of two multi-center European Commission-funded projects (HEPMEAP and PAMCHAR) concerning source-composition-toxicity relationship for particulate matter (PM) sampled i...

    Authors: Miriam E Gerlofs-Nijland, A John F Boere, Daan LAC Leseman, Jan AMA Dormans, Thomas Sandström, Raimo O Salonen, Leendert van Bree and Flemming R Cassee

    Citation: Particle and Fibre Toxicology 2005 2:2

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  26. Content type: Research

    Respiratory symptoms, impaired lung function, and asthma have been reported in workers exposed to wood dust in a number of epidemiological studies. The underlying pathomechanisms, however, are not well underst...

    Authors: Huayan Long, Tingming Shi, Paul J Borm, Juha Määttä, Kirsti Husgafvel-Pursiainen, Kai Savolainen and Fritz Krombach

    Citation: Particle and Fibre Toxicology 2004 1:3

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  27. Content type: Research

    Exposure to fine particulate matter air pollutants (PM2.5) affects heart rate variability parameters, and levels of serum proteins associated with inflammation, hemostasis and thrombosis. This study investigated ...

    Authors: Michael Riediker, Robert B Devlin, Thomas R Griggs, Margaret C Herbst, Philip A Bromberg, Ronald W Williams and Wayne E Cascio

    Citation: Particle and Fibre Toxicology 2004 1:2

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