Articles

Intravenous administration of silver nanoparticles causes organ toxicity through intracellular ROS-related loss of inter-endothelial junction

Administration of silver nanoparticles (AgNPs) to mice could result in their distribution and accumulation in multiple organs, with notable prominence in liver, lungs, and kidneys. However, how AgNPs transport...

Authors: Hua Guo, Jing Zhang, Mary Boudreau, Jie Meng, Jun-jie Yin, Jian Liu and Haiyan Xu

Aerosol generation and characterization of multi-walled carbon nanotubes exposed to cells cultured at the air-liquid interface

Aerosol generation and characterization are critical components in the assessment of the inhalation hazards of engineered nanomaterials (NMs). An extensive review was conducted on aerosol generation and exposu...

Authors: William W. Polk, Monita Sharma, Christie M. Sayes, Jon A. Hotchkiss and Amy J. Clippinger

Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages

Particulate matter has been shown to stimulate the innate immune system and induce acute inflammation. Therefore, while nanotechnology has the potential to provide therapeutic formulations with improved effica...

Authors: Caroline S. Hughes, Liza M. Colhoun, Baljinder K. Bains, Joanne D. Kilgour, Roberta E. Burden, James F. Burrows, Ed C. Lavelle, Brendan F. Gilmore and Christopher J. Scott

Eye irritation testing of nanomaterials using the EpiOcular™ eye irritation test and the bovine corneal opacity and permeability assay

Assessment of eye irritation hazard has long been a core requirement in any chemical legislation. Nevertheless, publications focussing on the eye damaging potential of nanomaterials are scarce. Traditionally, ...

Authors: Susanne N. Kolle, Ursula G. Sauer, Maria C. Rey Moreno, Wera Teubner, Wendel Wohlleben and Robert Landsiedel

Persistent effects of Libby amphibole and amosite asbestos following subchronic inhalation in rats

Human exposure to Libby amphibole (LA) asbestos increases risk of lung cancer, mesothelioma, and non-malignant respiratory disease. This study evaluated potency and time-course effects of LA and positive contr...

Authors: Stephen H. Gavett, Carl U. Parkinson, Gabrielle A. Willson, Charles E. Wood, Annie M. Jarabek, Kay C. Roberts, Urmila P. Kodavanti and Darol E. Dodd

Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation

Carbon nanotube (CNT) is used for various industrial purposes, but exhibits carcinogenic effects in experimental animals. Chronic inflammation in the respiratory system may participate in CNT-induced carcinoge...

Authors: Yusuke Hiraku, Feiye Guo, Ning Ma, Tatsuhiko Yamada, Shumin Wang, Shosuke Kawanishi and Mariko Murata

Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes

A diverse class of engineered nanomaterials (ENMs) exhibiting a wide array of physical-chemical properties that are associated with toxicological effects in experimental animals is in commercial use. However, ...

Authors: Sarah Labib, Andrew Williams, Carole L. Yauk, Jake K. Nikota, Håkan Wallin, Ulla Vogel and Sabina Halappanavar

Surface modification-mediated biodistribution of ¹³C-fullerene C₆₀ in vivo

Functionalization is believed to have a considerable impact on the biodistribution of fullerene in vivo. However, a direct comparison of differently functionalized fullerenes is required to prove the hypothesi...

Authors: Chenglong Wang, Yitong Bai, Hongliang Li, Rong Liao, Jiaxin Li, Han Zhang, Xian Zhang, Sujuan Zhang, Sheng-Tao Yang and Xue-Ling Chang

Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals

Air pollution from particulate matter (PM) has been linked to cardiovascular morbidity and mortality; however the underlying biological mechanisms remain to be uncovered. Gene regulation by microRNAs (miRNAs) ...

Authors: Rodosthenis S. Rodosthenous, Brent A. Coull, Quan Lu, Pantel S. Vokonas, Joel D. Schwartz and Andrea A. Baccarelli

Tissue distribution and acute toxicity of silver after single intravenous administration in mice: nano-specific and size-dependent effects

Silver nanoparticles (AgNPs) are an important class of nanomaterials used as antimicrobial agents for a wide range of medical and industrial applications. However toxicity of AgNPs and impact of their physicoc...

Authors: Camilla Recordati, Marcella De Maglie, Silvia Bianchessi, Simona Argentiere, Claudia Cella, Silvana Mattiello, Francesco Cubadda, Federica Aureli, Marilena D’Amato, Andrea Raggi, Cristina Lenardi, Paolo Milani and Eugenio Scanziani

Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP)

Several experimental studies have shown that carbon nanotubes (CNT) can induce respiratory effects, including lung fibrosis. The cellular and molecular events through which these effects develop are, however, ...

Authors: Giulia Vietti, Dominique Lison and Sybille van den Brule

Incomplete lung recovery following sub-acute inhalation of combustion-derived ultrafine particles in mice

Particulate matter (PM) is one of the six criteria pollutant classes for which National Ambient Air Quality Standards have been set by the United States Environmental Protection Agency. Exposures to PM have be...

Authors: A. Noël, R. Xiao, Z. Perveen, H. M. Zaman, R. L. Rouse, D. B. Paulsen and A. L. Penn

Effects of silver nanoparticles and ions on a co-culture model for the gastrointestinal epithelium

The increased incorporation of silver nanoparticles (Ag NPs) into consumer products makes the characterization of potential risk for humans and other organisms essential. The oral route is an important uptake ...

Authors: Anastasia Georgantzopoulou, Tommaso Serchi, Sébastien Cambier, Céline C. Leclercq, Jenny Renaut, Jia Shao, Marcin Kruszewski, Esther Lentzen, Patrick Grysan, Santhana Eswara, Jean-Nicolas Audinot, Servane Contal, Johanna Ziebel, Cédric Guignard, Lucien Hoffmann, AlberTinka J. Murk…

The influence of inhaled multi-walled carbon nanotubes on the autonomic nervous system

Heart rate and cardiovascular function are regulated by the autonomic nervous system. Heart rate variability (HRV) as a marker reflects the activity of autonomic nervous system. The prognostic significance of ...

Authors: W. Zheng, W. McKinney, M. Kashon, R. Salmen, V. Castranova and H. Kan

Biodistribution and toxicity of radio-labeled few layer graphene in mice after intratracheal instillation

The potential human health risks from graphene inhalation exposure have attracted substantial scientific interest as a result of the numerous exciting potential commercial applications of graphene. However, th...

Authors: Liang Mao, Maojie Hu, Bingcai Pan, Yongchao Xie and Elijah J. Petersen

Platelet activation independent of pulmonary inflammation contributes to diesel exhaust particulate-induced promotion of arterial thrombosis

Accelerated thrombus formation induced by exposure to combustion-derived air pollution has been linked to alterations in endogenous fibrinolysis and platelet activation in response to pulmonary and systemic in...

Authors: Caroline M. Tabor, Catherine A. Shaw, Sarah Robertson, Mark R. Miller, Rodger Duffin, Ken Donaldson, David E. Newby and Patrick W. F. Hadoke

Poorly soluble cobalt oxide particles trigger genotoxicity via multiple pathways

Poorly soluble cobalt (II, III) oxide particles (Co₃O₄P) are believed to induce in vitro cytotoxic effects via a Trojan-horse mechanism. Once internalized into lysosomal and acidic intracellular compartments, Co₃

Authors: Chiara Uboldi, Thierry Orsière, Carine Darolles, Valérie Aloin, Virginie Tassistro, Isabelle George and Véronique Malard

An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles

Due to the wide application of engineered aluminum oxide nanoparticles and increased aluminum containing particulate matter suspending in air, exposure of human to nano-scale aluminum oxide nanoparticles (Al₂O₃ N...

Authors: Xiaobo Li, Chengcheng Zhang, Xin Zhang, Shizhi Wang, Qingtao Meng, Shenshen Wu, Hongbao Yang, Yankai Xia and Rui Chen

Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses

Engineered nanomaterials (ENMs) interact with different biomolecules as soon as they are in contact, resulting in the formation of a biomolecule ‘corona’. Hence, the ‘corona’ defines the biological identity of...

Authors: Isabella Radauer-Preiml, Ancuela Andosch, Thomas Hawranek, Ursula Luetz-Meindl, Markus Wiederstein, Jutta Horejs-Hoeck, Martin Himly, Matthew Boyles and Albert Duschl

Morphometric analysis of inflammation in bronchial biopsies following exposure to inhaled diesel exhaust and allergen challenge in atopic subjects

Allergen exposure and air pollution are two risk factors for asthma development and airway inflammation that have been examined extensively in isolation. The impact of combined allergen and diesel exhaust expo...

Authors: Ali Hosseini, Jeremy A. Hirota, Tillie L. Hackett, Kelly M. McNagny, Susan J. Wilson and Chris Carlsten

Response to the Reply on behalf of the ‘Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area’ (MAK Commission) by Andrea Hartwig Karlsruhe Institute of Technology (KIT)

Authors: Peter Morfeld, Joachim Bruch, Len Levy, Yufanyi Ngiewih, Ishrat Chaudhuri, Henry J. Muranko, Ross Myerson and Robert J. McCunney

Proteomic analysis of protein carbonylation: a useful tool to unravel nanoparticle toxicity mechanisms

Oxidative stress, a commonly used paradigm to explain nanoparticle (NP)-induced toxicity, results from an imbalance between reactive oxygen species (ROS) generation and detoxification. As one consequence, prot...

Authors: Marc D. Driessen, Sarah Mues, Antje Vennemann, Bryan Hellack, Anne Bannuscher, Vishalini Vimalakanthan, Christian Riebeling, Rainer Ossig, Martin Wiemann, Jürgen Schnekenburger, Thomas A. J. Kuhlbusch, Bernhard Renard, Andreas Luch and Andrea Haase

Assessing particle and fiber toxicology in the respiratory system: the stereology toolbox

The inhalation of airborne particles can lead to pathological changes in the respiratory tract. For this reason, toxicology studies on effects of inhalable particles and fibers often include an assessment of h...

Authors: Christina Brandenberger, Matthias Ochs and Christian Mühlfeld

“Are we forgetting the smallest, sub 10 nm combustion generated particles?”

Although mass emissions of combustion-generated particulate matter have been substantially reduced by new combustion technology, there is still a great concern about the emissions of huge numbers of sub-10 nm ...

Authors: Paola Pedata, Tobias Stoeger, Ralf Zimmermann, Annette Peters, Günter Oberdörster and Andrea D’Anna

Acute exposure to wood smoke from incomplete combustion - indications of cytotoxicity

Smoke from combustion of biomass fuels is a major risk factor for respiratory disease, but the underlying mechanisms are poorly understood. The aim of this study was to determine whether exposure to wood smoke...

Authors: Ala Muala, Gregory Rankin, Maria Sehlstedt, Jon Unosson, Jenny A. Bosson, Annelie Behndig, Jamshid Pourazar, Robin Nyström, Esbjörn Pettersson, Christoffer Bergvall, Roger Westerholm, Pasi I. Jalava, Mikko S. Happo, Oskari Uski, Maija-Riitta Hirvonen, Frank J. Kelly…

Advanced computational modeling for in vitro nanomaterial dosimetry

Accurate and meaningful dose metrics are a basic requirement for in vitro screening to assess potential health risks of engineered nanomaterials (ENMs). Correctly and consistently quantifying what cells “see,” du...

Authors: Glen M. DeLoid, Joel M. Cohen, Georgios Pyrgiotakis, Sandra V. Pirela, Anoop Pal, Jiying Liu, Jelena Srebric and Philip Demokritou

Silica coating influences the corona and biokinetics of cerium oxide nanoparticles

The physicochemical properties of nanoparticles (NPs) influence their biological outcomes.

Authors: Nagarjun V. Konduru, Renato J. Jimenez, Archana Swami, Sherri Friend, Vincent Castranova, Philip Demokritou, Joseph D. Brain and Ramon M. Molina

Effects of prenatal inhalation exposure to copper nanoparticles on murine dams and offspring

Increasing numbers of individuals may be exposed to nanomaterials during pregnancy. The overarching goal of this investigation was to determine if prenatal inhalation exposure to copper nanoparticles (Cu NPs) ...

Authors: Andrea Adamcakova-Dodd, Martha M. Monick, Linda S. Powers, Katherine N. Gibson-Corley and Peter S. Thorne

Assessment of a panel of interleukin-8 reporter lung epithelial cell lines to monitor the pro-inflammatory response following zinc oxide nanoparticle exposure under different cell culture conditions

Stably transfected lung epithelial reporter cell lines pose an advantageous alternative to replace complex experimental techniques to monitor the pro-inflammatory response following nanoparticle (NP) exposure....

Authors: Linda C. Stoehr, Carola Endes, Isabella Radauer-Preiml, Matthew S. P. Boyles, Eudald Casals, Sandor Balog, Markus Pesch, Alke Petri-Fink, Barbara Rothen-Rutishauser, Martin Himly, Martin J. D. Clift and Albert Duschl

Nitrative stress, oxidative stress and plasma endothelin levels after inhalation of particulate matter and ozone

While exposure to ambient air contaminants is clearly associated with adverse health outcomes, disentangling mechanisms of pollutant interactions remains a challenge.

Authors: Prem Kumarathasan, Erica Blais, Anushuyadevi Saravanamuthu, Agnieszka Bielecki, Ballari Mukherjee, Stephen Bjarnason, Josée Guénette, Patrick Goegan and Renaud Vincent

Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat

Notwithstanding increasing knowledge of titanium dioxide nanoparticles (TiO₂ NPs) passing through biological barriers, their biodistribution to the central nervous system (CNS) and potential effects on blood-brai...

Authors: Clémence Disdier, Jérôme Devoy, Anne Cosnefroy, Monique Chalansonnet, Nathalie Herlin-Boime, Emilie Brun, Amie Lund and Aloïse Mabondzo

Pharmaceutical/food grade titanium dioxide particles are absorbed into the bloodstream of human volunteers

Exposure to persistent engineered nano and micro particles via the oral route is well established. Animal studies have demonstrated that, once ingested, a small proportion of such particles translocate from th...

Authors: Laetitia C. Pele, Vinay Thoree, Sylvaine FA Bruggraber, Dagmar Koller, Richard PH Thompson, Miranda C. Lomer and Jonathan J. Powell

Impact of nanosilver on various DNA lesions and HPRT gene mutations – effects of charge and surface coating

The main goal of this research was to study the interactions of a fully characterized set of silver nanomaterials (Ag ENMs) with cells in vitro, according to the standards of Good Laboratory Practices (GLP), to a...

Authors: Anna Huk, Emilia Izak-Nau, Naouale el Yamani, Hilde Uggerud, Marit Vadset, Beata Zasonska, Albert Duschl and Maria Dusinska

Cytotoxic and inflammatory potential of size-fractionated particulate matter collected repeatedly within a small urban area

Exposure to coarse, fine, and ultrafine particles is associated with adverse population health impacts. We investigated whether size-fractionated particles collected repeatedly in the vicinity of industrial (s...

Authors: Errol M. Thomson, Dalibor Breznan, Subramanian Karthikeyan, Christine MacKinnon-Roy, Jean-Pierre Charland, Ewa Dabek-Zlotorzynska, Valbona Celo, Prem Kumarathasan, Jeffrey R. Brook and Renaud Vincent

Retraction Note: Mechanisms of nanosized titanium dioxide-induced testicular oxidative stress and apoptosis in male mice

Authors: Xiaoyang Zhao, Lei Sheng, Ling Wang, Jie Hong, Xiaohong Yu, Xuezi Sang, Qingqing Sun, Yuguan Ze and Fashui Hong

Retraction Note: Intragastric exposure to titanium dioxide nanoparticles induced nephrotoxicity in mice, assessed by physiological and gene expression modifications

Authors: Suxin Gui, Xuezi Sang, Lei Zheng, Yuguan Ze, Xiaoyang Zhao, Lei Sheng, Qingqing Sun, Zhe Cheng, Jie Cheng, Renping Hu, Ling Wang, Fashui Hong and Meng Tang

Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes Graphistrength^© C100 after a 90-day nose-only inhalation exposure of rats

Graphistrength ^© C100 multiwalled carbon nanotubes (MWCNT) provide superior electrical and mechanical properties for various applications. The evaluation of the intrinsic ha...

Authors: Daniela Pothmann, Sophie Simar, Detlef Schuler, Eva Dony, Stéphane Gaering, Jean-Loïc Le Net, Yoshi Okazaki, Jean Michel Chabagno, Cécile Bessibes, Julien Beausoleil, Fabrice Nesslany and Jean-François Régnier

Preventing carbon nanoparticle-induced lung inflammation reduces antigen-specific sensitization and subsequent allergic reactions in a mouse model

Exposure of the airways to carbonaceous nanoparticles can contribute to the development of immune diseases both via the aggravation of the allergic immune response in sensitized individuals and by adjuvant mec...

Authors: Matthias Kroker, Ulrich Sydlik, Andrea Autengruber, Christian Cavelius, Heike Weighardt, Annette Kraegeloh and Klaus Unfried

Differential bioreactivity of neutral, cationic and anionic polystyrene nanoparticles with cells from the human alveolar compartment: robust response of alveolar type 1 epithelial cells

Engineered nanoparticles (NP) are being developed for inhaled drug delivery. This route is non-invasive and the major target; alveolar epithelium provides a large surface area for drug administration and absor...

Authors: Pakatip Ruenraroengsak and Teresa D. Tetley

Translocation of gold nanoparticles across the lung epithelial tissue barrier: Combining in vitro and in silico methods to substitute in vivo experiments

The lung epithelial tissue barrier represents the main portal for entry of inhaled nanoparticles (NPs) into the systemic circulation. Thus great efforts are currently being made to determine adverse health eff...

Authors: Gerald Bachler, Sabrina Losert, Yuki Umehara, Natalie von Goetz, Laura Rodriguez-Lorenzo, Alke Petri-Fink, Barbara Rothen-Rutishauser and Konrad Hungerbuehler

Acute and subchronic exposure to air particulate matter induces expression of angiotensin and bradykinin-related genes in the lungs and heart: Angiotensin-II type-I receptor as a molecular target of particulate matter exposure

Particulate matter (PM) adverse effects on health include lung and heart damage. The renin-angiotensin-aldosterone (RAAS) and kallikrein-kinin (KKS) endocrine systems are involved in the pathophysiology of car...

Authors: Octavio Gamaliel Aztatzi-Aguilar, Marisela Uribe-Ramírez, José Antonio Arias-Montaño, Olivier Barbier and Andrea De Vizcaya-Ruiz

Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice

The skin is a key route of human exposure to nanomaterials, which typically occurs simultaneously with exposure to other chemical and environmental allergen. However, little is known about the hazards of nanom...

Authors: Toshiro Hirai, Yasuo Yoshioka, Hideki Takahashi, Ko-ichi Ichihashi, Asako Udaka, Takahide Mori, Nobuo Nishijima, Tokuyuki Yoshida, Kazuya Nagano, Haruhiko Kamada, Shin-ichi Tsunoda, Tatsuya Takagi, Ken J. Ishii, Hiromi Nabeshi, Tomoaki Yoshikawa, Kazuma Higashisaka…

Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats

Exposure to ambient PM_2.5 increases cardiovascular mortality and morbidity. To delineate the underlying biological mechanism, we investigated the time dependence of cardiovascular response to chronic exposure to ...

Authors: Zhekang Ying, Xiaoyun Xie, Yuntao Bai, Minjie Chen, Xiaoke Wang, Xuan Zhang, Masako Morishita, Qinghua Sun and Sanjay Rajagopalan

Metal rich particulate matter impairs acetylcholine-mediated vasorelaxation of microvessels in mice

Exposure to PM_2.5 (particulate matter <2.5 μm) has been associated with changes in endothelial function. PM_2.5 was collected from two Chinese cities, Jinchang (JC) and Zhangye (ZH), both with similar PM_2.5 concen...

Authors: Azita K Cuevas, Jingping Niu, Mianhua Zhong, Eric N Liberda, Andrew Ghio, Qingshan Qu and Lung Chi Chen

Response-metrics for acute lung inflammation pattern by cobalt-based nanoparticles

Although the surface area metric has been proposed as a possible dose-metric for nanoparticles (NPs), it is limited to low-solubility NPs and the dose-metric for high-solubility NPs is poorly understood. In th...

Authors: Jiyoung Jeong, Youngju Han, Craig A. Poland and Wan-Seob Cho

Cardiac effects of seasonal ambient particulate matter and ozone co-exposure in rats

The potential for seasonal differences in the physicochemical characteristics of ambient particulate matter (PM) to modify interactive effects with gaseous pollutants has not been thoroughly examined. The purp...

Authors: Aimen K Farraj, Leon Walsh, Najwa Haykal-Coates, Fatiha Malik, John McGee, Darrell Winsett, Rachelle Duvall, Kasey Kovalcik, Wayne E Cascio, Mark Higuchi and Mehdi S Hazari

Dissolution and biodurability: Important parameters needed for risk assessment of nanomaterials

Biopersistence and biodurability have the potential to influence the long-term toxicity and hence pathogenicity of particles that deposit in the body. Therefore, biopersistence and biodurability are considered...

Authors: Wells Utembe, Kariska Potgieter, Aleksandr Byron Stefaniak and Mary Gulumian

Lung particle overload: old school –new insights?

Authors: Paul Borm, Flemming R Cassee and Günter Oberdörster

Translational toxicology in setting occupational exposure limits for dusts and hazard classification – a critical evaluation of a recent approach to translate dust overload findings from rats to humans

We analyze the scientific basis and methodology used by the German MAK Commission in their recommendations for exposure limits and carcinogen classification of “granular biopersistent particles without known s...

Authors: Peter Morfeld, Joachim Bruch, Len Levy, Yufanyi Ngiewih, Ishrat Chaudhuri, Henry J Muranko, Ross Myerson and Robert J McCunney

Elevated particle number concentrations induce immediate changes in heart rate variability: a panel study in individuals with impaired glucose metabolism or diabetes

The health effects of short-term exposure to ambient ultrafine particles in micro-environments are still under investigation.

Authors: Annette Peters, Regina Hampel, Josef Cyrys, Susanne Breitner, Uta Geruschkat, Ute Kraus, Wojciech Zareba and Alexandra Schneider