Articles

Advanced computational modeling for in vitro nanomaterial dosimetry

Accurate and meaningful dose metrics are a basic requirement for in vitro screening to assess potential health risks of engineered nanomaterials (ENMs). Correctly and consistently quantifying what cells “see,” du...

Authors: Glen M. DeLoid, Joel M. Cohen, Georgios Pyrgiotakis, Sandra V. Pirela, Anoop Pal, Jiying Liu, Jelena Srebric and Philip Demokritou

Silica coating influences the corona and biokinetics of cerium oxide nanoparticles

The physicochemical properties of nanoparticles (NPs) influence their biological outcomes.

Authors: Nagarjun V. Konduru, Renato J. Jimenez, Archana Swami, Sherri Friend, Vincent Castranova, Philip Demokritou, Joseph D. Brain and Ramon M. Molina

Effects of prenatal inhalation exposure to copper nanoparticles on murine dams and offspring

Increasing numbers of individuals may be exposed to nanomaterials during pregnancy. The overarching goal of this investigation was to determine if prenatal inhalation exposure to copper nanoparticles (Cu NPs) ...

Authors: Andrea Adamcakova-Dodd, Martha M. Monick, Linda S. Powers, Katherine N. Gibson-Corley and Peter S. Thorne

Assessment of a panel of interleukin-8 reporter lung epithelial cell lines to monitor the pro-inflammatory response following zinc oxide nanoparticle exposure under different cell culture conditions

Stably transfected lung epithelial reporter cell lines pose an advantageous alternative to replace complex experimental techniques to monitor the pro-inflammatory response following nanoparticle (NP) exposure....

Authors: Linda C. Stoehr, Carola Endes, Isabella Radauer-Preiml, Matthew S. P. Boyles, Eudald Casals, Sandor Balog, Markus Pesch, Alke Petri-Fink, Barbara Rothen-Rutishauser, Martin Himly, Martin J. D. Clift and Albert Duschl

Nitrative stress, oxidative stress and plasma endothelin levels after inhalation of particulate matter and ozone

While exposure to ambient air contaminants is clearly associated with adverse health outcomes, disentangling mechanisms of pollutant interactions remains a challenge.

Authors: Prem Kumarathasan, Erica Blais, Anushuyadevi Saravanamuthu, Agnieszka Bielecki, Ballari Mukherjee, Stephen Bjarnason, Josée Guénette, Patrick Goegan and Renaud Vincent

Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat

Notwithstanding increasing knowledge of titanium dioxide nanoparticles (TiO₂ NPs) passing through biological barriers, their biodistribution to the central nervous system (CNS) and potential effects on blood-brai...

Authors: Clémence Disdier, Jérôme Devoy, Anne Cosnefroy, Monique Chalansonnet, Nathalie Herlin-Boime, Emilie Brun, Amie Lund and Aloïse Mabondzo

Pharmaceutical/food grade titanium dioxide particles are absorbed into the bloodstream of human volunteers

Exposure to persistent engineered nano and micro particles via the oral route is well established. Animal studies have demonstrated that, once ingested, a small proportion of such particles translocate from th...

Authors: Laetitia C. Pele, Vinay Thoree, Sylvaine FA Bruggraber, Dagmar Koller, Richard PH Thompson, Miranda C. Lomer and Jonathan J. Powell

Impact of nanosilver on various DNA lesions and HPRT gene mutations – effects of charge and surface coating

The main goal of this research was to study the interactions of a fully characterized set of silver nanomaterials (Ag ENMs) with cells in vitro, according to the standards of Good Laboratory Practices (GLP), to a...

Authors: Anna Huk, Emilia Izak-Nau, Naouale el Yamani, Hilde Uggerud, Marit Vadset, Beata Zasonska, Albert Duschl and Maria Dusinska

Cytotoxic and inflammatory potential of size-fractionated particulate matter collected repeatedly within a small urban area

Exposure to coarse, fine, and ultrafine particles is associated with adverse population health impacts. We investigated whether size-fractionated particles collected repeatedly in the vicinity of industrial (s...

Authors: Errol M. Thomson, Dalibor Breznan, Subramanian Karthikeyan, Christine MacKinnon-Roy, Jean-Pierre Charland, Ewa Dabek-Zlotorzynska, Valbona Celo, Prem Kumarathasan, Jeffrey R. Brook and Renaud Vincent

Retraction Note: Mechanisms of nanosized titanium dioxide-induced testicular oxidative stress and apoptosis in male mice

Authors: Xiaoyang Zhao, Lei Sheng, Ling Wang, Jie Hong, Xiaohong Yu, Xuezi Sang, Qingqing Sun, Yuguan Ze and Fashui Hong

Retraction Note: Intragastric exposure to titanium dioxide nanoparticles induced nephrotoxicity in mice, assessed by physiological and gene expression modifications

Authors: Suxin Gui, Xuezi Sang, Lei Zheng, Yuguan Ze, Xiaoyang Zhao, Lei Sheng, Qingqing Sun, Zhe Cheng, Jie Cheng, Renping Hu, Ling Wang, Fashui Hong and Meng Tang

Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes Graphistrength^© C100 after a 90-day nose-only inhalation exposure of rats

Graphistrength ^© C100 multiwalled carbon nanotubes (MWCNT) provide superior electrical and mechanical properties for various applications. The evaluation of the intrinsic ha...

Authors: Daniela Pothmann, Sophie Simar, Detlef Schuler, Eva Dony, Stéphane Gaering, Jean-Loïc Le Net, Yoshi Okazaki, Jean Michel Chabagno, Cécile Bessibes, Julien Beausoleil, Fabrice Nesslany and Jean-François Régnier

Preventing carbon nanoparticle-induced lung inflammation reduces antigen-specific sensitization and subsequent allergic reactions in a mouse model

Exposure of the airways to carbonaceous nanoparticles can contribute to the development of immune diseases both via the aggravation of the allergic immune response in sensitized individuals and by adjuvant mec...

Authors: Matthias Kroker, Ulrich Sydlik, Andrea Autengruber, Christian Cavelius, Heike Weighardt, Annette Kraegeloh and Klaus Unfried

Differential bioreactivity of neutral, cationic and anionic polystyrene nanoparticles with cells from the human alveolar compartment: robust response of alveolar type 1 epithelial cells

Engineered nanoparticles (NP) are being developed for inhaled drug delivery. This route is non-invasive and the major target; alveolar epithelium provides a large surface area for drug administration and absor...

Authors: Pakatip Ruenraroengsak and Teresa D. Tetley

Translocation of gold nanoparticles across the lung epithelial tissue barrier: Combining in vitro and in silico methods to substitute in vivo experiments

The lung epithelial tissue barrier represents the main portal for entry of inhaled nanoparticles (NPs) into the systemic circulation. Thus great efforts are currently being made to determine adverse health eff...

Authors: Gerald Bachler, Sabrina Losert, Yuki Umehara, Natalie von Goetz, Laura Rodriguez-Lorenzo, Alke Petri-Fink, Barbara Rothen-Rutishauser and Konrad Hungerbuehler

Acute and subchronic exposure to air particulate matter induces expression of angiotensin and bradykinin-related genes in the lungs and heart: Angiotensin-II type-I receptor as a molecular target of particulate matter exposure

Particulate matter (PM) adverse effects on health include lung and heart damage. The renin-angiotensin-aldosterone (RAAS) and kallikrein-kinin (KKS) endocrine systems are involved in the pathophysiology of car...

Authors: Octavio Gamaliel Aztatzi-Aguilar, Marisela Uribe-Ramírez, José Antonio Arias-Montaño, Olivier Barbier and Andrea De Vizcaya-Ruiz

Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice

The skin is a key route of human exposure to nanomaterials, which typically occurs simultaneously with exposure to other chemical and environmental allergen. However, little is known about the hazards of nanom...

Authors: Toshiro Hirai, Yasuo Yoshioka, Hideki Takahashi, Ko-ichi Ichihashi, Asako Udaka, Takahide Mori, Nobuo Nishijima, Tokuyuki Yoshida, Kazuya Nagano, Haruhiko Kamada, Shin-ichi Tsunoda, Tatsuya Takagi, Ken J. Ishii, Hiromi Nabeshi, Tomoaki Yoshikawa, Kazuma Higashisaka…

Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats

Exposure to ambient PM_2.5 increases cardiovascular mortality and morbidity. To delineate the underlying biological mechanism, we investigated the time dependence of cardiovascular response to chronic exposure to ...

Authors: Zhekang Ying, Xiaoyun Xie, Yuntao Bai, Minjie Chen, Xiaoke Wang, Xuan Zhang, Masako Morishita, Qinghua Sun and Sanjay Rajagopalan

Metal rich particulate matter impairs acetylcholine-mediated vasorelaxation of microvessels in mice

Exposure to PM_2.5 (particulate matter <2.5 μm) has been associated with changes in endothelial function. PM_2.5 was collected from two Chinese cities, Jinchang (JC) and Zhangye (ZH), both with similar PM_2.5 concen...

Authors: Azita K Cuevas, Jingping Niu, Mianhua Zhong, Eric N Liberda, Andrew Ghio, Qingshan Qu and Lung Chi Chen

Response-metrics for acute lung inflammation pattern by cobalt-based nanoparticles

Although the surface area metric has been proposed as a possible dose-metric for nanoparticles (NPs), it is limited to low-solubility NPs and the dose-metric for high-solubility NPs is poorly understood. In th...

Authors: Jiyoung Jeong, Youngju Han, Craig A. Poland and Wan-Seob Cho

Cardiac effects of seasonal ambient particulate matter and ozone co-exposure in rats

The potential for seasonal differences in the physicochemical characteristics of ambient particulate matter (PM) to modify interactive effects with gaseous pollutants has not been thoroughly examined. The purp...

Authors: Aimen K Farraj, Leon Walsh, Najwa Haykal-Coates, Fatiha Malik, John McGee, Darrell Winsett, Rachelle Duvall, Kasey Kovalcik, Wayne E Cascio, Mark Higuchi and Mehdi S Hazari

Dissolution and biodurability: Important parameters needed for risk assessment of nanomaterials

Biopersistence and biodurability have the potential to influence the long-term toxicity and hence pathogenicity of particles that deposit in the body. Therefore, biopersistence and biodurability are considered...

Authors: Wells Utembe, Kariska Potgieter, Aleksandr Byron Stefaniak and Mary Gulumian

Lung particle overload: old school –new insights?

Authors: Paul Borm, Flemming R Cassee and Günter Oberdörster

Translational toxicology in setting occupational exposure limits for dusts and hazard classification – a critical evaluation of a recent approach to translate dust overload findings from rats to humans

We analyze the scientific basis and methodology used by the German MAK Commission in their recommendations for exposure limits and carcinogen classification of “granular biopersistent particles without known s...

Authors: Peter Morfeld, Joachim Bruch, Len Levy, Yufanyi Ngiewih, Ishrat Chaudhuri, Henry J Muranko, Ross Myerson and Robert J McCunney

Elevated particle number concentrations induce immediate changes in heart rate variability: a panel study in individuals with impaired glucose metabolism or diabetes

The health effects of short-term exposure to ambient ultrafine particles in micro-environments are still under investigation.

Authors: Annette Peters, Regina Hampel, Josef Cyrys, Susanne Breitner, Uta Geruschkat, Ute Kraus, Wojciech Zareba and Alexandra Schneider

Oral absorption of PEG-coated versus uncoated gold nanospheres: does agglomeration matter?

Particle size is thought to be a critical factor affecting the bioavailability of nanoparticles following oral exposure. Nearly all studies of nanoparticle bioavailability focus on characterization of the prim...

Authors: Georgia K Hinkley, Paul Carpinone, John W Munson, Kevin W Powers and Stephen M Roberts

Size-fractioned ultrafine particles and black carbon associated with autonomic dysfunction in subjects with diabetes or impaired glucose tolerance in Shanghai, China

Particles in smaller size fractions, such as ultrafine particles (UFPs) (with diameter less than 100 nm), has become of significant cardiovascular health concerns. However, the biological plausibility underlyi...

Authors: Yitong Sun, Xiaoming Song, Yiqun Han, Yunfang Ji, Shuna Gao, Yu Shang, Shou-en Lu, Tong Zhu and Wei Huang

Controlled exposure to particulate matter from urban street air is associated with decreased vasodilation and heart rate variability in overweight and older adults

Exposure to particulate matter (PM) is generally associated with elevated risk of cardiovascular morbidity and mortality. Elderly and obese subjects may be particularly susceptible, although short-term effects...

Authors: Jette G Hemmingsen, Jenny Rissler, Jens Lykkesfeldt, Gerd Sallsten, Jesper Kristiansen, Peter Møller P and Steffen Loft

Comparison of cellular toxicity caused by ambient ultrafine particles and engineered metal oxide nanoparticles

The development of nanotechnology has spurred concerns about the health effects of exposure to nanoparticles (NPs) and ultrafine particles (UFPs). Toxicological data on NPs and UFPs may provide evidence to sup...

Authors: Senlin Lu, Wenchao Zhang, Rui Zhang, Pinwei Liu, Qiangxiang Wang, Yu Shang, Minghong Wu, Ken Donaldson and Qingyue Wang

Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice

Nanoparticles have become a key technology in multiple industries. However, there are growing reports of the toxicity of nanomaterials to humans. In particular, nanomaterials have been linked to lung diseases....

Authors: Yang Sun, Feng Guo, Zhen Zou, Chenggang Li, Xiaoxu Hong, Yan Zhao, Chenxuan Wang, Hongliang Wang, Haolin Liu, Peng Yang, Zongsheng Han, Kangtai Liu, Keiji Kuba, Bin Song, Jinming Gao, Ziyao Mo…

Nanodiamonds act as Trojan horse for intracellular delivery of metal ions to trigger cytotoxicity

Nanomaterials hold great promise for applications in the delivery of various molecules with poor cell penetration, yet its potential for delivery of metal ions is rarely considered. Particularly, there is limi...

Authors: Ying Zhu, Yu Zhang, Guosheng Shi, Jinrong Yang, Jichao Zhang, Wenxin Li, Aiguo Li, Renzhong Tai, Haiping Fang, Chunhai Fan and Qing Huang

Acute exposure to silica nanoparticles enhances mortality and increases lung permeability in a mouse model of Pseudomonas aeruginosa pneumonia

The lung epithelium constitutes the first barrier against invading pathogens and also a major surface potentially exposed to nanoparticles. In order to ensure and preserve lung epithelial barrier function, the...

Authors: Mathilde Delaval, Sonja Boland, Brigitte Solhonne, Marie-Anne Nicola, Stéphane Mornet, Armelle Baeza-Squiban, Jean-Michel Sallenave and Ignacio Garcia-Verdugo

In vitro investigation of silica nanoparticle uptake into human endothelial cells under physiological cyclic stretch

In general the prediction of the toxicity and therapeutic efficacy of engineered nanoparticles in humans is initially determined using in vitro static cell culture assays. However, such test systems may not be su...

Authors: Christian Freese, Daniel Schreiner, Laura Anspach, Christoph Bantz, Michael Maskos, Ronald E Unger and C James Kirkpatrick

Derivation of occupational exposure levels (OELs) of Low-toxicity isometric biopersistent particles: how can the kinetic lung overload paradigm be used for improved inhalation toxicity study design and OEL-derivation?

Convincing evidence suggests that poorly soluble low-toxicity particles (PSP) exert two unifying major modes of action (MoA), in which one appears to be deposition-related acute, whilst the other is retention-...

Authors: Jürgen Pauluhn

Why does the hemolytic activity of silica predict its pro-inflammatory activity?

The hemolytic activity of inhaled particles such as silica has been widely investigated in the past and represents a usual toxicological endpoint to characterize particle reactivity despite the fact that red b...

Authors: Cristina Pavan, Virginie Rabolli, Maura Tomatis, Bice Fubini and Dominique Lison

Diesel exhaust particle exposure in vitro impacts T lymphocyte phenotype and function

Diesel exhaust particles (DEP) are major constituents of ambient air pollution and their adverse health effect is an area of intensive investigations. With respect to the immune system, DEP have attracted sign...

Authors: Marina Pierdominici, Angela Maselli, Serena Cecchetti, Antonella Tinari, Arianna Mastrofrancesco, Michela Alfè, Valentina Gargiulo, Carlo Beatrice, Gabriele Di Blasio, Giulia Carpinelli, Elena Ortona, Antonello Giovannetti and Silvana Fiorito

Reduced pulmonary function and increased pro-inflammatory cytokines in nanoscale carbon black-exposed workers

Although major concerns exist regarding the potential consequences of human exposures to nanoscale carbon black (CB) particles, limited human toxicological data is currently available. The purpose of this stud...

Authors: Rong Zhang, Yufei Dai, Xiao Zhang, Yong Niu, Tao Meng, Yuanyuan Li, Huawei Duan, Ping Bin, Meng Ye, Xiaowei Jia, Meili Shen, Shanfa Yu, Xiaofa Yang, Weimin Gao and Yuxin Zheng

Nanometer-long Ge-imogolite nanotubes cause sustained lung inflammation and fibrosis in rats

Ge-imogolites are short aluminogermanate tubular nanomaterials with attractive prospected industrial applications. In view of their nano-scale dimensions and high aspect ratio, they should be examined for thei...

Authors: Sybille van den Brule, Emilie Beckers, Perrine Chaurand, Wei Liu, Saloua Ibouraadaten, Mihaly Palmai-Pallag, Francine Uwambayinema, Yousof Yakoub, Astrid Avellan, Clément Levard, Vincent Haufroid, Etienne Marbaix, Antoine Thill, Dominique Lison and Jérôme Rose

Single-walled carbon nanotubes increase pandemic influenza A H1N1 virus infectivity of lung epithelial cells

Airborne exposure to nanomaterials from unintended occupational or environmental exposures or as a consequence of product use may lead to adverse health effects. Numerous studies have focused on single-walled ...

Authors: Pallab Sanpui, Xiao Zheng, Julia C Loeb, Joseph H Bisesi Jr, Iftheker A Khan, A R M Nabiul Afrooz, Keira Liu, Appala Raju Badireddy, Mark R Wiesner, P Lee Ferguson, Navid B Saleh, John A Lednicky and Tara Sabo-Attwood

The alarmin IL-1α is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticles

Inflammasome-activated IL-1β plays a major role in lung neutrophilic inflammation induced by inhaled silica. However, the exact mechanisms that contribute to the initial production of precursor IL-1β (pro-IL-1...

Authors: Virginie Rabolli, Anissa Alami Badissi, Raynal Devosse, Francine Uwambayinema, Yousof Yakoub, Mihaly Palmai-Pallag, Astrid Lebrun, Valentin De Gussem, Isabelle Couillin, Bernard Ryffel, Etienne Marbaix, Dominique Lison and François Huaux

Short-term diesel exhaust inhalation in a controlled human crossover study is associated with changes in DNA methylation of circulating mononuclear cells in asthmatics

Changes in DNA methylation have been associated with traffic-related air pollution in observational studies, but the specific mechanisms and temporal dynamics therein have not been explored in a controlled stu...

Authors: Ruiwei Jiang, Meaghan J Jones, Francesco Sava, Michael S Kobor and Christopher Carlsten

Exposure to traffic-related air pollution during physical activity and acute changes in blood pressure, autonomic and micro-vascular function in women: a cross-over study

Traffic-related air pollution may contribute to cardiovascular morbidity. In urban areas, exposures during physical activity are of interest owing to increased breathing rates and close proximity to vehicle em...

Authors: Scott Weichenthal, Marianne Hatzopoulou and Mark S Goldberg

Titanium dioxide nanoparticles promote arrhythmias via a direct interaction with rat cardiac tissue

In light of recent developments in nanotechnologies, interest is growing to better comprehend the interaction of nanoparticles with body tissues, in particular within the cardiovascular system. Attention has r...

Authors: Monia Savi, Stefano Rossi, Leonardo Bocchi, Laura Gennaccaro, Francesca Cacciani, Alessio Perotti, Davide Amidani, Rossella Alinovi, Matteo Goldoni, Irene Aliatis, Pier Paolo Lottici, Danilo Bersani, Marco Campanini, Silvana Pinelli, Marta Petyx, Caterina Frati…

Effect of wood smoke exposure on vascular function and thrombus formation in healthy fire fighters

Myocardial infarction is the leading cause of death in fire fighters and has been linked with exposure to air pollution and fire suppression duties. We therefore investigated the effects of wood smoke exposure...

Authors: Amanda L Hunter, Jon Unosson, Jenny A Bosson, Jeremy P Langrish, Jamshid Pourazar, Jennifer B Raftis, Mark R Miller, Andrew J Lucking, Christoffer Boman, Robin Nyström, Kenneth Donaldson, Andrew D Flapan, Anoop SV Shah, Louis Pung, Ioannis Sadiktsis, Silvia Masala…

Is the toxic potential of nanosilver dependent on its size?

Nanosilver is one of the most commonly used engineered nanomaterials (ENMs). In our study we focused on assessing the size-dependence of the toxicity of nanosilver (Ag ENMs), utilising materials of three sizes...

Authors: Anna Huk, Emilia Izak-Nau, Bogumila Reidy, Matthew Boyles, Albert Duschl, Iseult Lynch and Maria Dušinska

Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum

The complement system is a key component of innate immunity implicated in the neutralization and clearance of invading pathogens. Dextran coated superparamagnetic iron oxide (SPIO) nanoparticle is a promising ...

Authors: Nirmal K Banda, Gaurav Mehta, Ying Chao, Guankui Wang, Swetha Inturi, Liliane Fossati-Jimack, Marina Botto, LinPing Wu, Seyed Moein Moghimi and Dmitri Simberg

Role of microbial and chemical composition in toxicological properties of indoor and outdoor air particulate matter

Ambient air particulate matter (PM) is increasingly considered to be a causal factor evoking severe adverse health effects. People spend the majority of their time indoors, which should be taken into account e...

Authors: Mikko S Happo, Olli Sippula, Pasi I Jalava, Helena Rintala, Ari Leskinen, Mika Komppula, Kari Kuuspalo, Santtu Mikkonen, Kari Lehtinen, Jorma Jokiniemi and Maija-Riitta Hirvonen

The carcinogenic effect of various multi-walled carbon nanotubes (MWCNTs) after intraperitoneal injection in rats

Biological effects of tailor-made multi-walled carbon nanotubes (MWCNTs) without functionalization were investigated in vivo in a two-year carcinogenicity study. In the past, intraperitoneal carcinogenicity studi...

Authors: Susanne Rittinghausen, Anja Hackbarth, Otto Creutzenberg, Heinrich Ernst, Uwe Heinrich, Albrecht Leonhardt and Dirk Schaudien

Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

Mineral particles in the lung cause inflammation and silicosis. In myeloid and bronchial epithelial cells the inflammasome plays a role in responses to crystalline silica. Thioredoxin (TRX) and its inhibitory ...

Authors: Paul M Peeters, Irene M J Eurlings, Timothy N Perkins, Emiel F Wouters, Roel P F Schins, Paul J A Borm, Wolfgang Drommer, Niki L Reynaert and Catrin Albrecht

Pulmonary and hemostatic toxicity of multi-walled carbon nanotubes and zinc oxide nanoparticles after pulmonary exposure in Bmal1 knockout mice

Pulmonary exposure to nanoparticles (NPs) may affect, in addition to pulmonary toxicity, the cardiovascular system such as procoagulant effects, vascular dysfunction and progression of atherosclerosis. However...

Authors: Katrien Luyts, Stijn Smulders, Dorota Napierska, Soetkin Van kerckhoven, Katrien Poels, Hans Scheers, Bianca Hemmeryckx, Ben Nemery, Marc F Hoylaerts and Peter H M Hoet