Articles

In vivo biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles in rats

Cerium oxide (CeO₂) nanoparticles used as a diesel fuel additive can be emitted into the ambient air leading to human inhalation. Although biological studies have shown CeO₂ nanoparticles can cause adverse health...

Authors: Dingsheng Li, Masako Morishita, James G. Wagner, Mohammad Fatouraie, Margaret Wooldridge, W. Ethan Eagle, James Barres, Ulrika Carlander, Claude Emond and Olivier Jolliet

Long-term exposure to commercially available sunscreens containing nanoparticles of TiO₂ and ZnO revealed no biological impact in a hairless mouse model

The application of sunscreen is a critical component of a sun-safe strategy, however the possibility of unexpected, adverse outcomes resulting from long-term use of sunscreens containing nanoparticles of titan...

Authors: Megan J. Osmond-McLeod, Yalchin Oytam, Anthony Rowe, Fariborz Sobhanmanesh, Gavin Greenoak, Jason Kirby, Elizabeth F. McInnes and Maxine J. McCall

Erratum to: Surface modification-mediated biodistribution of ¹³C-fullerene C₆₀ in vivo

Authors: Chenglong Wang, Yitong Bai, Hongliang Li, Rong Liao, Jiaxin Li, Han Zhang, Xian Zhang, Sujuan Zhang, Sheng-Tao Yang and Xue-Ling Chang

Differential pulmonary effects of CoO and La₂O₃ metal oxide nanoparticle responses during aerosolized inhalation in mice

Although classified as metal oxides, cobalt monoxide (CoO) and lanthanum oxide (La₂O₃) nanoparticles, as representative transition and rare earth oxides, exhibit distinct material properties that may result in di...

Authors: Jennifer D. Sisler, Ruibin Li, Walter McKinney, Robert R. Mercer, Zhaoxia Ji, Tian Xia, Xiang Wang, Justine Shaffer, Marlene Orandle, Amy L. Mihalchik, Lori Battelli, Bean T. Chen, Michael Wolfarth, Michael E. Andrew, Diane Schwegler-Berry, Dale W. Porter…

Development of an integrated approach for comparison of in vitro and in vivo responses to particulate matter

Association of particulate matter with adverse health effects has been established in epidemiological studies and animal experiments. Epidemiological studies are difficult to undertake while animal studies are...

Authors: Dalibor Breznan, Subramanian Karthikeyan, Marcelle Phaneuf, Prem Kumarathasan, Sabit Cakmak, Michael S. Denison, Jeffrey R. Brook and Renaud Vincent

The complex cascade of cellular events governing inflammasome activation and IL-1β processing in response to inhaled particles

The innate immune system is the first line of defense against inhaled particles. Macrophages serve important roles in particle clearance and inflammatory reactions. Following recognition and internalization by...

Authors: Virginie Rabolli, Dominique Lison and François Huaux

Maternal exposure to diluted diesel engine exhaust alters placental function and induces intergenerational effects in rabbits

Airborne pollution is a rising concern in urban areas. Epidemiological studies in humans and animal experiments using rodent models indicate that gestational exposure to airborne pollution, in particular diese...

Authors: Sarah A. Valentino, Anne Tarrade, Josiane Aioun, Eve Mourier, Christophe Richard, Michèle Dahirel, Delphine Rousseau-Ralliard, Natalie Fournier, Marie-Christine Aubrière, Marie-Sylvie Lallemand, Sylvaine Camous, Marine Guinot, Madia Charlier, Etienne Aujean, Hala Al Adhami, Paul H. Fokkens…

Dietary silver nanoparticles can disturb the gut microbiota in mice

Humans are increasingly exposed via the diet to Ag nanoparticles (NP) used in the food industry. Because of their anti-bacterial activity, ingested Ag NP might disturb the gut microbiota that is essential for ...

Authors: Sybille van den Brule, Jérôme Ambroise, Hélène Lecloux, Clément Levard, Romain Soulas, Pieter-Jan De Temmerman, Mihaly Palmai-Pallag, Etienne Marbaix and Dominique Lison

Epoxy composite dusts with and without carbon nanotubes cause similar pulmonary responses, but differences in liver histology in mice following pulmonary deposition

The toxicity of dusts from mechanical abrasion of multi-walled carbon nanotube (CNT) epoxy nanocomposites is unknown. We compared the toxic effects of dusts generated by sanding of epoxy composites with and wi...

Authors: Anne Thoustrup Saber, Alicja Mortensen, Józef Szarek, Ismo Kalevi Koponen, Marcus Levin, Nicklas Raun Jacobsen, Maria Elena Pozzebon, Stefano Pozzi Mucelli, David George Rickerby, Kirsten Kling, Rambabu Atluri, Anne Mette Madsen, Petra Jackson, Zdenka Orabi Kyjovska, Ulla Vogel, Keld Alstrup Jensen…

Titanium dioxide nanoparticles induce the expression of early and late receptors for adhesion molecules on monocytes

There is growing evidence that exposure to titanium dioxide nanoparticles (TiO₂ NPs) could be harmful. Previously, we have shown that TiO₂ NPs induces endothelial cell dysfunction and damage in glial cells. Consi...

Authors: Cristhiam Rueda-Romero, Guillermina Hernández-Pérez, Pilar Ramos-Godínez, Inés Vázquez-López, Raúl Omar Quintana-Belmares, Elizabeth Huerta-García, Ewa Stepien, Rebeca López-Marure, Angélica Montiel-Dávalos and Ernesto Alfaro-Moreno

Erratum to: Silica coating influences the corona and biokinetics of cerium oxide nanoparticles

Authors: Nagarjun V. Konduru, Renato J. Jimenez, Archana Swami, Sherri Friend, Vincent Castranova, Philip Demokritou, Joseph D. Brain and Ramon M. Molina

Evaluation of pulmonary and systemic toxicity following lung exposure to graphite nanoplates: a member of the graphene-based nanomaterial family

Graphene, a monolayer of carbon, is an engineered nanomaterial (ENM) with physical and chemical properties that may offer application advantages over other carbonaceous ENMs, such as carbon nanotubes (CNT). Th...

Authors: Jenny R. Roberts, Robert R. Mercer, Aleksandr B. Stefaniak, Mohindar S. Seehra, Usha K. Geddam, Ishrat S. Chaudhuri, Angelos Kyrlidis, Vamsi K. Kodali, Tina Sager, Allison Kenyon, Suzan A. Bilgesu, Tracy Eye, James F. Scabilloni, Stephen S. Leonard, Natalie R. Fix, Diane Schwegler-Berry…

No involvement of alveolar macrophages in the initiation of carbon nanoparticle induced acute lung inflammation in mice

Carbonaceous nanoparticles (CNP) represent a major constituent of urban particulate air pollution, and inhalation of high CNP levels has been described to trigger a pro-inflammatory response of the lung. While...

Authors: Shanze Chen, Renfu Yin, Kathrin Mutze, Youjia Yu, Shinji Takenaka, Melanie Königshoff and Tobias Stoeger

Revisiting the paradigm of silica pathogenicity with synthetic quartz crystals: the role of crystallinity and surface disorder

Exposure to some - but not all - quartz particles is associated to silicosis, lung cancer and autoimmune diseases. What imparts pathogenicity to any single quartz source is however still unclear. Crystallinity...

Authors: Francesco Turci, Cristina Pavan, Riccardo Leinardi, Maura Tomatis, Linda Pastero, David Garry, Sergio Anguissola, Dominique Lison and Bice Fubini

Increase in oxidative stress levels following welding fume inhalation: a controlled human exposure study

Tungsten inert gas (TIG) welding represents one of the most widely used metal joining processes in industry. It has been shown to generate a large majority of particles at the nanoscale and to have low mass em...

Authors: Halshka Graczyk, Nastassja Lewinski, Jiayuan Zhao, Jean-Jacques Sauvain, Guillaume Suarez, Pascal Wild, Brigitta Danuser and Michael Riediker

Nickel oxide nanoparticles can recruit eosinophils in the lungs of rats by the direct release of intracellular eotaxin

Instillation of highly soluble nanoparticles (NPs) into the lungs of rodents can cause acute eosinophilia without any previous sensitizations by the role of dissolved ions. However, whether gradually dissolvin...

Authors: Seonghan Lee, Sung-Hyun Hwang, Jiyoung Jeong, Youngju Han, Sung-Hyun Kim, Dong-Keon Lee, Hae-Suk Lee, Seung-Tae Chung, Jayoung Jeong, Changhyun Roh, Yun Seok Huh and Wan-Seob Cho

Atomic layer deposition coating of carbon nanotubes with zinc oxide causes acute phase immune responses in human monocytes in vitro and in mice after pulmonary exposure

Atomic layer deposition (ALD) is a method for applying conformal nanoscale coatings on three-dimensional structures. We hypothesized that surface functionalization of multi-walled carbon nanotubes (MWCNTs) wit...

Authors: Erinn C. Dandley, Alexia J. Taylor, Katherine S. Duke, Mark D. Ihrie, Kelly A. Shipkowski, Gregory N. Parsons and James C. Bonner

Gender differences in murine pulmonary responses elicited by cellulose nanocrystals

Cellulose-based materials have been used for centuries to manufacture different goods derived from forestry and agricultural sources. In the growing field of nanocellulose applications, its uniquely engineered...

Authors: Anna A. Shvedova, Elena R. Kisin, Naveena Yanamala, Mariana T. Farcas, Autumn L. Menas, Andrew Williams, Philip M. Fournier, Jeffrey S. Reynolds, Dmitriy W. Gutkin, Alexander Star, Richard S. Reiner, Sabina Halappanavar and Valerian E. Kagan

Multi-walled carbon nanotubes directly induce epithelial-mesenchymal transition in human bronchial epithelial cells via the TGF-β-mediated Akt/GSK-3β/SNAIL-1 signalling pathway

Multi-walled carbon nanotubes (MWCNT) are currently under intense toxicological investigation due to concern on their potential health effects. Current in vitro and in vivo data indicate that MWCNT exposure is...

Authors: Manuela Polimeni, Giulia Rossana Gulino, Elena Gazzano, Joanna Kopecka, Arianna Marucco, Ivana Fenoglio, Federico Cesano, Luisa Campagnolo, Andrea Magrini, Antonio Pietroiusti, Dario Ghigo and Elisabetta Aldieri

Effects of urban fine particulate matter and ozone on HDL functionality

Exposures to ambient particulate matter (PM) are associated with increased morbidity and mortality. PM_2.5 (<2.5 μm) and ozone exposures have been shown to associate with carotid intima media thickness in humans. ...

Authors: Gajalakshmi Ramanathan, Fen Yin, Mary Speck, Chi-hong Tseng, Jeffrey R. Brook, Frances Silverman, Bruce Urch, Robert D. Brook and Jesus A. Araujo

Meta-analysis of transcriptomic responses as a means to identify pulmonary disease outcomes for engineered nanomaterials

The increasing use of engineered nanomaterials (ENMs) of varying physical and chemical characteristics poses a great challenge for screening and assessing the potential pathology induced by these materials, ne...

Authors: Jake Nikota, Andrew Williams, Carole L. Yauk, Håkan Wallin, Ulla Vogel and Sabina Halappanavar

Diesel exposure suppresses natural killer cell function and resolution of eosinophil inflammation: a randomized controlled trial of exposure in allergic rhinitics

Exposure to diesel exhaust (DE) is known to exacerbate allergic inflammation, including virus-induced eosinophil activation in laboratory animals. We have previously shown that in human volunteers with allergi...

Authors: Erica A. Pawlak, Terry L. Noah, Haibo Zhou, Claire Chehrazi, Carole Robinette, David Diaz-Sanchez, Loretta Müller and Ilona Jaspers

Direct stimulation of human fibroblasts by nCeO₂ in vitro is attenuated with an amorphous silica coating

Nano-scaled cerium oxide (nCeO₂) is used in a variety of applications, including use as a fuel additive, catalyst, and polishing agent, yet potential adverse health effects associated with nCeO₂ exposure remain i...

Authors: Donna C. Davidson, Raymond Derk, Xiaoqing He, Todd A. Stueckle, Joel Cohen, Sandra V. Pirela, Philip Demokritou, Yon Rojanasakul and Liying Wang

Ultrasmall superparamagnetic iron oxide nanoparticles acutely promote thrombosis and cardiac oxidative stress and DNA damage in mice

Ultrasmall superparamagnetic iron oxide nanoparticles (USPIO) are being developed for several biomedical applications including drug delivery and imaging. However, little is known about their possible adverse ...

Authors: Abderrahim Nemmar, Sumaya Beegam, Priya Yuvaraju, Javed Yasin, Saeed Tariq, Samir Attoub and Badreldin H. Ali

Intravenous administration of silver nanoparticles causes organ toxicity through intracellular ROS-related loss of inter-endothelial junction

Administration of silver nanoparticles (AgNPs) to mice could result in their distribution and accumulation in multiple organs, with notable prominence in liver, lungs, and kidneys. However, how AgNPs transport...

Authors: Hua Guo, Jing Zhang, Mary Boudreau, Jie Meng, Jun-jie Yin, Jian Liu and Haiyan Xu

Aerosol generation and characterization of multi-walled carbon nanotubes exposed to cells cultured at the air-liquid interface

Aerosol generation and characterization are critical components in the assessment of the inhalation hazards of engineered nanomaterials (NMs). An extensive review was conducted on aerosol generation and exposu...

Authors: William W. Polk, Monita Sharma, Christie M. Sayes, Jon A. Hotchkiss and Amy J. Clippinger

Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages

Particulate matter has been shown to stimulate the innate immune system and induce acute inflammation. Therefore, while nanotechnology has the potential to provide therapeutic formulations with improved effica...

Authors: Caroline S. Hughes, Liza M. Colhoun, Baljinder K. Bains, Joanne D. Kilgour, Roberta E. Burden, James F. Burrows, Ed C. Lavelle, Brendan F. Gilmore and Christopher J. Scott

Eye irritation testing of nanomaterials using the EpiOcular™ eye irritation test and the bovine corneal opacity and permeability assay

Assessment of eye irritation hazard has long been a core requirement in any chemical legislation. Nevertheless, publications focussing on the eye damaging potential of nanomaterials are scarce. Traditionally, ...

Authors: Susanne N. Kolle, Ursula G. Sauer, Maria C. Rey Moreno, Wera Teubner, Wendel Wohlleben and Robert Landsiedel

Persistent effects of Libby amphibole and amosite asbestos following subchronic inhalation in rats

Human exposure to Libby amphibole (LA) asbestos increases risk of lung cancer, mesothelioma, and non-malignant respiratory disease. This study evaluated potency and time-course effects of LA and positive contr...

Authors: Stephen H. Gavett, Carl U. Parkinson, Gabrielle A. Willson, Charles E. Wood, Annie M. Jarabek, Kay C. Roberts, Urmila P. Kodavanti and Darol E. Dodd

Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation

Carbon nanotube (CNT) is used for various industrial purposes, but exhibits carcinogenic effects in experimental animals. Chronic inflammation in the respiratory system may participate in CNT-induced carcinoge...

Authors: Yusuke Hiraku, Feiye Guo, Ning Ma, Tatsuhiko Yamada, Shumin Wang, Shosuke Kawanishi and Mariko Murata

Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes

A diverse class of engineered nanomaterials (ENMs) exhibiting a wide array of physical-chemical properties that are associated with toxicological effects in experimental animals is in commercial use. However, ...

Authors: Sarah Labib, Andrew Williams, Carole L. Yauk, Jake K. Nikota, Håkan Wallin, Ulla Vogel and Sabina Halappanavar

Surface modification-mediated biodistribution of ¹³C-fullerene C₆₀ in vivo

Functionalization is believed to have a considerable impact on the biodistribution of fullerene in vivo. However, a direct comparison of differently functionalized fullerenes is required to prove the hypothesi...

Authors: Chenglong Wang, Yitong Bai, Hongliang Li, Rong Liao, Jiaxin Li, Han Zhang, Xian Zhang, Sujuan Zhang, Sheng-Tao Yang and Xue-Ling Chang

Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals

Air pollution from particulate matter (PM) has been linked to cardiovascular morbidity and mortality; however the underlying biological mechanisms remain to be uncovered. Gene regulation by microRNAs (miRNAs) ...

Authors: Rodosthenis S. Rodosthenous, Brent A. Coull, Quan Lu, Pantel S. Vokonas, Joel D. Schwartz and Andrea A. Baccarelli

Tissue distribution and acute toxicity of silver after single intravenous administration in mice: nano-specific and size-dependent effects

Silver nanoparticles (AgNPs) are an important class of nanomaterials used as antimicrobial agents for a wide range of medical and industrial applications. However toxicity of AgNPs and impact of their physicoc...

Authors: Camilla Recordati, Marcella De Maglie, Silvia Bianchessi, Simona Argentiere, Claudia Cella, Silvana Mattiello, Francesco Cubadda, Federica Aureli, Marilena D’Amato, Andrea Raggi, Cristina Lenardi, Paolo Milani and Eugenio Scanziani

Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP)

Several experimental studies have shown that carbon nanotubes (CNT) can induce respiratory effects, including lung fibrosis. The cellular and molecular events through which these effects develop are, however, ...

Authors: Giulia Vietti, Dominique Lison and Sybille van den Brule

Incomplete lung recovery following sub-acute inhalation of combustion-derived ultrafine particles in mice

Particulate matter (PM) is one of the six criteria pollutant classes for which National Ambient Air Quality Standards have been set by the United States Environmental Protection Agency. Exposures to PM have be...

Authors: A. Noël, R. Xiao, Z. Perveen, H. M. Zaman, R. L. Rouse, D. B. Paulsen and A. L. Penn

Effects of silver nanoparticles and ions on a co-culture model for the gastrointestinal epithelium

The increased incorporation of silver nanoparticles (Ag NPs) into consumer products makes the characterization of potential risk for humans and other organisms essential. The oral route is an important uptake ...

Authors: Anastasia Georgantzopoulou, Tommaso Serchi, Sébastien Cambier, Céline C. Leclercq, Jenny Renaut, Jia Shao, Marcin Kruszewski, Esther Lentzen, Patrick Grysan, Santhana Eswara, Jean-Nicolas Audinot, Servane Contal, Johanna Ziebel, Cédric Guignard, Lucien Hoffmann, AlberTinka J. Murk…

The influence of inhaled multi-walled carbon nanotubes on the autonomic nervous system

Heart rate and cardiovascular function are regulated by the autonomic nervous system. Heart rate variability (HRV) as a marker reflects the activity of autonomic nervous system. The prognostic significance of ...

Authors: W. Zheng, W. McKinney, M. Kashon, R. Salmen, V. Castranova and H. Kan

Biodistribution and toxicity of radio-labeled few layer graphene in mice after intratracheal instillation

The potential human health risks from graphene inhalation exposure have attracted substantial scientific interest as a result of the numerous exciting potential commercial applications of graphene. However, th...

Authors: Liang Mao, Maojie Hu, Bingcai Pan, Yongchao Xie and Elijah J. Petersen

Platelet activation independent of pulmonary inflammation contributes to diesel exhaust particulate-induced promotion of arterial thrombosis

Accelerated thrombus formation induced by exposure to combustion-derived air pollution has been linked to alterations in endogenous fibrinolysis and platelet activation in response to pulmonary and systemic in...

Authors: Caroline M. Tabor, Catherine A. Shaw, Sarah Robertson, Mark R. Miller, Rodger Duffin, Ken Donaldson, David E. Newby and Patrick W. F. Hadoke

Poorly soluble cobalt oxide particles trigger genotoxicity via multiple pathways

Poorly soluble cobalt (II, III) oxide particles (Co₃O₄P) are believed to induce in vitro cytotoxic effects via a Trojan-horse mechanism. Once internalized into lysosomal and acidic intracellular compartments, Co₃

Authors: Chiara Uboldi, Thierry Orsière, Carine Darolles, Valérie Aloin, Virginie Tassistro, Isabelle George and Véronique Malard

An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles

Due to the wide application of engineered aluminum oxide nanoparticles and increased aluminum containing particulate matter suspending in air, exposure of human to nano-scale aluminum oxide nanoparticles (Al₂O₃ N...

Authors: Xiaobo Li, Chengcheng Zhang, Xin Zhang, Shizhi Wang, Qingtao Meng, Shenshen Wu, Hongbao Yang, Yankai Xia and Rui Chen

Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses

Engineered nanomaterials (ENMs) interact with different biomolecules as soon as they are in contact, resulting in the formation of a biomolecule ‘corona’. Hence, the ‘corona’ defines the biological identity of...

Authors: Isabella Radauer-Preiml, Ancuela Andosch, Thomas Hawranek, Ursula Luetz-Meindl, Markus Wiederstein, Jutta Horejs-Hoeck, Martin Himly, Matthew Boyles and Albert Duschl

Morphometric analysis of inflammation in bronchial biopsies following exposure to inhaled diesel exhaust and allergen challenge in atopic subjects

Allergen exposure and air pollution are two risk factors for asthma development and airway inflammation that have been examined extensively in isolation. The impact of combined allergen and diesel exhaust expo...

Authors: Ali Hosseini, Jeremy A. Hirota, Tillie L. Hackett, Kelly M. McNagny, Susan J. Wilson and Chris Carlsten

Response to the Reply on behalf of the ‘Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area’ (MAK Commission) by Andrea Hartwig Karlsruhe Institute of Technology (KIT)

Authors: Peter Morfeld, Joachim Bruch, Len Levy, Yufanyi Ngiewih, Ishrat Chaudhuri, Henry J. Muranko, Ross Myerson and Robert J. McCunney

Proteomic analysis of protein carbonylation: a useful tool to unravel nanoparticle toxicity mechanisms

Oxidative stress, a commonly used paradigm to explain nanoparticle (NP)-induced toxicity, results from an imbalance between reactive oxygen species (ROS) generation and detoxification. As one consequence, prot...

Authors: Marc D. Driessen, Sarah Mues, Antje Vennemann, Bryan Hellack, Anne Bannuscher, Vishalini Vimalakanthan, Christian Riebeling, Rainer Ossig, Martin Wiemann, Jürgen Schnekenburger, Thomas A. J. Kuhlbusch, Bernhard Renard, Andreas Luch and Andrea Haase

Assessing particle and fiber toxicology in the respiratory system: the stereology toolbox

The inhalation of airborne particles can lead to pathological changes in the respiratory tract. For this reason, toxicology studies on effects of inhalable particles and fibers often include an assessment of h...

Authors: Christina Brandenberger, Matthias Ochs and Christian Mühlfeld

“Are we forgetting the smallest, sub 10 nm combustion generated particles?”

Although mass emissions of combustion-generated particulate matter have been substantially reduced by new combustion technology, there is still a great concern about the emissions of huge numbers of sub-10 nm ...

Authors: Paola Pedata, Tobias Stoeger, Ralf Zimmermann, Annette Peters, Günter Oberdörster and Andrea D’Anna

Acute exposure to wood smoke from incomplete combustion - indications of cytotoxicity

Smoke from combustion of biomass fuels is a major risk factor for respiratory disease, but the underlying mechanisms are poorly understood. The aim of this study was to determine whether exposure to wood smoke...

Authors: Ala Muala, Gregory Rankin, Maria Sehlstedt, Jon Unosson, Jenny A. Bosson, Annelie Behndig, Jamshid Pourazar, Robin Nyström, Esbjörn Pettersson, Christoffer Bergvall, Roger Westerholm, Pasi I. Jalava, Mikko S. Happo, Oskari Uski, Maija-Riitta Hirvonen, Frank J. Kelly…

Advanced computational modeling for in vitro nanomaterial dosimetry

Accurate and meaningful dose metrics are a basic requirement for in vitro screening to assess potential health risks of engineered nanomaterials (ENMs). Correctly and consistently quantifying what cells “see,” du...

Authors: Glen M. DeLoid, Joel M. Cohen, Georgios Pyrgiotakis, Sandra V. Pirela, Anoop Pal, Jiying Liu, Jelena Srebric and Philip Demokritou