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Page 9 of 13

  1. In myeloid cells the inflammasome plays a crucial role in innate immune defenses against pathogen- and danger-associated patterns such as crystalline silica. Respirable mineral particles impinge upon the lung ...

    Authors: Paul M Peeters, Timothy N Perkins, Emiel FM Wouters, Brooke T Mossman and Niki L Reynaert

    Citation: Particle and Fibre Toxicology 2013 10:3

    Content type: Research

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  2. The uptake of nanoparticles (NPs) by cells remains to be better characterized in order to understand the mechanisms of potential NP toxicity as well as for a reliable risk assessment. Real NP uptake is still d...

    Authors: Sandra Vranic, Nicole Boggetto, Vincent Contremoulins, Stéphane Mornet, Nora Reinhardt, Francelyne Marano, Armelle Baeza-Squiban and Sonja Boland

    Citation: Particle and Fibre Toxicology 2013 10:2

    Content type: Research

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  3. The deposition, clearance and translocation of europium-doped gadolinium oxide nanoparticles in a mouse lung were investigated experimentally. Nanoparticles were synthesized by spray flame pyrolysis. The parti...

    Authors: Aamir D Abid, Donald S Anderson, Gautom K Das, Laura S Van Winkle and Ian M Kennedy

    Citation: Particle and Fibre Toxicology 2013 10:1

    Content type: Research

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  4. Ambient air pollution has been associated with activation of systemic inflammation and hypercoagulability and increased plasma homocysteine, but the chemical constituents behind the association are not well un...

    Authors: Shaowei Wu, Furong Deng, Hongying Wei, Jing Huang, Hongyi Wang, Masayuki Shima, Xin Wang, Yu Qin, Chanjuan Zheng, Yu Hao and Xinbiao Guo

    Citation: Particle and Fibre Toxicology 2012 9:49

    Content type: Research

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  5. Particulate air pollution in lung epithelial cells induces pathogenic endpoints like proliferation, apoptosis, and pro-inflammatory reactions. The activation of the epidermal growth factor receptor (EGFR) is a...

    Authors: Henrike Peuschel, Ulrich Sydlik, Susanne Grether-Beck, Ingo Felsner, Daniel Stöckmann, Sascha Jakob, Matthias Kroker, Judith Haendeler, Marijan Gotić, Christiane Bieschke, Jean Krutmann and Klaus Unfried

    Citation: Particle and Fibre Toxicology 2012 9:48

    Content type: Research

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  6. The objective of this study was to examine the threshold fibre length for the onset of pulmonary inflammation after aspiration exposure in mice to four different lengths of silver nanowires (AgNW). We further ...

    Authors: Anja Schinwald, Tanya Chernova and Ken Donaldson

    Citation: Particle and Fibre Toxicology 2012 9:47

    Content type: Research

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  7. Given the increasing use of carbon nanotubes (CNT) in composite materials and their possible expansion to new areas such as nanomedicine which will both lead to higher human exposure, a better understanding of...

    Authors: Cyrill Bussy, Mathieu Pinault, Julien Cambedouzou, Marion Julie Landry, Pascale Jegou, Martine Mayne-L'hermite, Pascale Launois, Jorge Boczkowski and Sophie Lanone

    Citation: Particle and Fibre Toxicology 2012 9:46

    Content type: Research

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  8. Exposure to particulate matter (PM) has been linked to several adverse cardiopulmonary effects, probably via biological mechanisms involving inflammation. The pro-inflammatory potential of PM depends on the pa...

    Authors: Anette Kocbach Bølling, Annike Irene Totlandsdal, Gerd Sallsten, Artur Braun, Roger Westerholm, Christoffer Bergvall, Johan Boman, Hans Jørgen Dahlman, Maria Sehlstedt, Flemming Cassee, Thomas Sandstrom, Per E Schwarze and Jan Inge Herseth

    Citation: Particle and Fibre Toxicology 2012 9:45

    Content type: Research

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  9. Respirable crystalline silica (RCS) continues to pose a risk to human health worldwide. Its variable toxicity depends on inherent characteristics and external factors which influence surface chemistry. Signifi...

    Authors: Claire J Horwell, Benedict J Williamson, Ken Donaldson, Jennifer S Le Blond, David E Damby and Leon Bowen

    Citation: Particle and Fibre Toxicology 2012 9:44

    Content type: Research

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  10. Epidemiologic studies associate childhood exposure to traffic-related air pollution with increased respiratory infections and asthmatic and allergic symptoms. The strongest associations between traffic exposur...

    Authors: Nicholas D Manzo, Adriana J LaGier, Ralph Slade, Allen D Ledbetter, Judy H Richards and Janice A Dye

    Citation: Particle and Fibre Toxicology 2012 9:43

    Content type: Research

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  11. In a recent work published in Particle and Fibre Toxicology by Fisichella and coworkers investigating surface-modified TiO2 nanoparticle exposure in a model human intestinal epithelium (Caco-2), albeit degraded t...

    Authors: James J Faust, Wen Zhang, Brian A Koeneman, Yongsheng Chen and David G Capco

    Citation: Particle and Fibre Toxicology 2012 9:42

    Content type: Letter to the Editor

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  12. Nanomaterials can be contaminated with endotoxin (lipopolysaccharides, LPS) during production or handling. In this study, we searched for a convenient in vitro method to evaluate endotoxin contamination in nanopa...

    Authors: Stijn Smulders, Jean-Pierre Kaiser, Stefano Zuin, Kirsten L Van Landuyt, Luana Golanski, Jeroen Vanoirbeek, Peter Wick and Peter HM Hoet

    Citation: Particle and Fibre Toxicology 2012 9:41

    Content type: Research

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  13. It has been well recognized that toxicity of fine ambient air particulate matter (PM2.5) may depend on its chemical constituents, including components such as soluble metals that may theoretically exert distincti...

    Authors: Xiaohua Xu, Xiaoquan Rao, Tse-Yao Wang, Silis Y Jiang, Zhekang Ying, Cuiqing Liu, Aixia Wang, Mianhua Zhong, Jeffrey A Deiuliis, Andrei Maiseyeu, Sanjay Rajagopalan, Morton Lippmann, Lung-Chi Chen and Qinghua Sun

    Citation: Particle and Fibre Toxicology 2012 9:40

    Content type: Research

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  14. In this response, we discuss the major differences that clearly distinguish our results from those mentioned by Faust et al. In particular, the experiments have been conducted on nanoparticles of different nat...

    Authors: Matthieu Fisichella, Frédéric Bérenguer, Gérard Steinmetz, Mélanie Auffan, Jérôme Rose and Odette Prat

    Citation: Particle and Fibre Toxicology 2012 9:39

    Content type: Letter to the Editor

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  15. The exceptional physical-chemical properties of carbon nanotubes have lead to their use in diverse commercial and biomedical applications. However, their utilization has raised concerns about human exposure th...

    Authors: Rakhee N Urankar, Robert M Lust, Erin Mann, Pranita Katwa, Xiaojia Wang, Ramakrishna Podila, Susana C Hilderbrand, Benjamin S Harrison, Pengyu Chen, Pu Chun Ke, Apparao M Rao, Jared M Brown and Christopher J Wingard

    Citation: Particle and Fibre Toxicology 2012 9:38

    Content type: Research

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  16. One of the major areas for increasing the use of renewable energy is in traffic fuels e.g. bio-based fuels in diesel engines especially in commuter traffic. Exhaust emissions from fossil diesel fuelled engines...

    Authors: Pasi I Jalava, Päivi Aakko-Saksa, Timo Murtonen, Mikko S Happo, Ari Markkanen, Pasi Yli-Pirilä, Pasi Hakulinen, Risto Hillamo, Jorma Mäki-Paakkanen, Raimo O Salonen, Jorma Jokiniemi and Maija-Riitta Hirvonen

    Citation: Particle and Fibre Toxicology 2012 9:37

    Content type: Research

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  17. Inorganic particles, such as drug carriers or contrast agents, are often introduced into the vascular system. Many key components of the in vivo vascular environment include monocyte-endothelial cell interactions...

    Authors: Xin Liu, Yang Xue, Tingting Ding and Jiao Sun

    Citation: Particle and Fibre Toxicology 2012 9:36

    Content type: Research

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  18. Exposure to particulate matter (PM) is a significant risk factor for increased cardiopulmonary morbidity and mortality. The mechanism of PM-mediated pathophysiology remains unknown. However, PM is proinflammat...

    Authors: Ting Wang, Lichun Wang, Liliana Moreno-Vinasco, Gabriel D Lang, Jessica H Siegler, Biji Mathew, Peter V Usatyuk, Jonathan M Samet, Alison S Geyh, Patrick N Breysse, Viswanathan Natarajan and Joe G N Garcia

    Citation: Particle and Fibre Toxicology 2012 9:35

    Content type: Research

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  19. Frustrated phagocytosis has been stated as an important factor in the initiation of an inflammatory response after fibre exposure. The length of fibrous structures has been linked to the potential of fibres to...

    Authors: Anja Schinwald and Ken Donaldson

    Citation: Particle and Fibre Toxicology 2012 9:34

    Content type: Methodology

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  20. Predominantly, studies of nanoparticle (NPs) toxicology in vitro are based upon the exposure of submerged cell cultures to particle suspensions. Such an approach however, does not reflect particle inhalation. As ...

    Authors: David O Raemy, Robert N Grass, Wendelin J Stark, Christoph M Schumacher, Martin JD Clift, Peter Gehr and Barbara Rothen-Rutishauser

    Citation: Particle and Fibre Toxicology 2012 9:33

    Content type: Research

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  21. Respirable crystalline silica (silicon dioxide; SiO2, quartz) particles are known to induce chronic inflammation and lung disease upon long-term inhalation, whereas non-crystalline (amorphous) SiO2 particles in t...

    Authors: Wiggo J Sandberg, Marit Låg, Jørn A Holme, Bernd Friede, Maurizio Gualtieri, Marcin Kruszewski, Per E Schwarze, Tonje Skuland and Magne Refsnes

    Citation: Particle and Fibre Toxicology 2012 9:32

    Content type: Research

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  22. Diesel exhaust particles (DEP) contribute substantially to ambient particulate matter (PM) air pollution in urban areas. Inhalation of PM has been associated with increased incidence of lung disease in suscept...

    Authors: Weidong Wu, David B Peden, Rob McConnell, Scott Fruin and David Diaz-Sanchez

    Citation: Particle and Fibre Toxicology 2012 9:31

    Content type: Research

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  23. Air pollution, mainly from combustion, is one of the leading global health risk factors. A susceptible group is the more than 200 million people worldwide suffering from chronic obstructive pulmonary disease (...

    Authors: Jakob Löndahl, Erik Swietlicki, Jenny Rissler, Agneta Bengtsson, Christoffer Boman, Anders Blomberg and Thomas Sandström

    Citation: Particle and Fibre Toxicology 2012 9:30

    Content type: Research

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  24. Mechanisms for cellular uptake of nanoparticles have important implications for nanoparticulate drug delivery and toxicity. We have explored the mechanism of uptake of amorphous silica nanoparticles of 14 nm d...

    Authors: Qingshan Mu, Nicole S Hondow, Łukasz Krzemiński, Andy P Brown, Lars JC Jeuken and Michael N Routledge

    Citation: Particle and Fibre Toxicology 2012 9:29

    Content type: Research

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  25. Following exposure via inhalation, intratracheal instillation or ingestion some nanomaterials (NM) have been shown to translocate to the liver. Since oxidative stress has been implicated as a possible mechanis...

    Authors: Ali Kermanizadeh, Birgit K Gaiser, Gary R Hutchison and Vicki Stone

    Citation: Particle and Fibre Toxicology 2012 9:28

    Content type: Research

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  26. Exposure to ultrafine particles exerts diverse harmful effects including aggravation of pulmonary diseases like asthma. Recently we demonstrated in a mouse model for allergic airway inflammation that particle-...

    Authors: Ingrid Beck-Speier, Erwin Karg, Heidrun Behrendt, Tobias Stoeger and Francesca Alessandrini

    Citation: Particle and Fibre Toxicology 2012 9:27

    Content type: Research

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  27. Data from environmental exposure to nanoparticles (NPs) suggest that chronic exposure may increase the incidence of lung, cardiovascular and neurodegenerative diseases. Impairment of cell function by intracell...

    Authors: Eleonore Fröhlich, Claudia Meindl, Eva Roblegg, Birgit Ebner, Markus Absenger and Thomas R Pieber

    Citation: Particle and Fibre Toxicology 2012 9:26

    Content type: Research

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  28. Welding, a process that generates an aerosol containing gases and metal-rich particulates, induces adverse physiological effects including inflammation, immunosuppression and cardiovascular dysfunction. This s...

    Authors: Aaron Erdely, James M Antonini, Rebecca Salmen-Muniz, Angie Liston, Tracy Hulderman, Petia P Simeonova, Michael L Kashon, Shengqiao Li, Ja K Gu, Samuel Stone, Bean T Chen, David G Frazer and Patti C Zeidler-Erdely

    Citation: Particle and Fibre Toxicology 2012 9:25

    Content type: Research

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  29. Particulate air pollution is associated with increased risk of cardiovascular disease and stroke. Although the precise mechanisms underlying this association are still unclear, the induction of systemic inflam...

    Authors: Dai-Hua Tsai, Nadia Amyai, Pedro Marques-Vidal, Jia-Lin Wang, Michael Riediker, Vincent Mooser, Fred Paccaud, Gerard Waeber, Peter Vollenweider and Murielle Bochud

    Citation: Particle and Fibre Toxicology 2012 9:24

    Content type: Research

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  30. The use of gold nanoparticles (AuNPs) for diagnostic applications and for drug and gene-delivery is currently under intensive investigation. For such applications, biocompatibility and the absence of cytotoxic...

    Authors: Christian Freese, Chiara Uboldi, Matthew I Gibson, Ronald E Unger, Babette B Weksler, Ignacio A Romero, Pierre-Olivier Couraud and C James Kirkpatrick

    Citation: Particle and Fibre Toxicology 2012 9:23

    Content type: Research

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  31. Aluminum oxide-based nanowhiskers (AO nanowhiskers) have been used in manufacturing processes as catalyst supports, flame retardants, adsorbents, or in ceramic, metal and plastic composite materials. They are ...

    Authors: Andrea Adamcakova-Dodd, Larissa V Stebounova, Patrick T O’Shaughnessy, Jong Sung Kim, Vicki H Grassian and Peter S Thorne

    Citation: Particle and Fibre Toxicology 2012 9:22

    Content type: Research

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  32. Particulate matter (PM) pollution is responsible for hundreds of thousands of deaths worldwide, the majority due to cardiovascular disease (CVD). While many potential pathophysiological mechanisms have been pr...

    Authors: Thomas J Grahame and Richard B Schlesinger

    Citation: Particle and Fibre Toxicology 2012 9:21

    Content type: Review

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  33. Particulate air pollution has been linked to an increased risk of cardiovascular disease and cancer. Animal studies have shown that inhalation of air particulates induces mutations in the male germline. Expand...

    Authors: Anne Mette Zenner Boisen, Thomas Shipley, Petra Jackson, Karin Sørig Hougaard, Håkan Wallin, Carole L Yauk and Ulla Vogel

    Citation: Particle and Fibre Toxicology 2012 9:19

    Content type: Short report

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  34. Titanium dioxide (TiO2) nanoparticles (NPs) are widely used due to their specific properties, like UV filters in sunscreen. In that particular case TiO2 NPs are surface modified to avoid photocatalytic effects. T...

    Authors: Matthieu Fisichella, Frederic Berenguer, Gerard Steinmetz, Melanie Auffan, Jerome Rose and Odette Prat

    Citation: Particle and Fibre Toxicology 2012 9:18

    Content type: Research

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  35. Increasing concern has been expressed regarding the potential adverse health effects that may be associated with human exposure to inhaled multi-walled carbon nanotubes (MWCNTs). Thus it is imperative that an ...

    Authors: Michael Gasser, Peter Wick, Martin JD Clift, Fabian Blank, Liliane Diener, Bing Yan, Peter Gehr, Harald F Krug and Barbara Rothen-Rutishauser

    Citation: Particle and Fibre Toxicology 2012 9:17

    Content type: Research

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  36. Single-walled carbon nanotubes (SWCNT) trigger pronounced inflammation and fibrosis in the lungs of mice following administration via pharyngeal aspiration or inhalation. Human exposure to SWCNT in an occupati...

    Authors: Linda Swedin, Romanico Arrighi, Britta Andersson-Willman, Ashley Murray, Yunying Chen, Mikael C I Karlsson, Susanna Kumlien Georén, Alexey V Tkach, Anna A Shvedova, Bengt Fadeel, Antonio Barragan and Annika Scheynius

    Citation: Particle and Fibre Toxicology 2012 9:16

    Content type: Research

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  37. We determined the ability of a model nanoparticle (NP) (titanium dioxide, TiO2) to modulate sensitization induced by a known potent dermal sensitizer (dinitrochlorobenzene) using a variant of the local lymph node...

    Authors: Salik Hussain, Stijn Smulders, Vanessa De Vooght, Bert Ectors, Sonja Boland, Francelyne Marano, Kirsten L Van Landuyt, Benoit Nemery, Peter HM Hoet and Jeroen AJ Vanoirbeek

    Citation: Particle and Fibre Toxicology 2012 9:15

    Content type: Research

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  38. Carbon nanotubes (CNTs) are engineered graphene cylinders with numerous applications in engineering, electronics and medicine. However, CNTs cause inflammation and fibrosis in the rodent lung, suggesting a pot...

    Authors: Jong Kwon Lee, Brian C Sayers, Kyung-Soo Chun, Huei-Chen Lao, Jeanette K Shipley-Phillips, James C Bonner and Robert Langenbach

    Citation: Particle and Fibre Toxicology 2012 9:14

    Content type: Research

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  39. Particle toxicology arose in order to understand the mechanisms of adverse effects of 3 major particle types that had historically exerted the greatest toll of ill-health—quartz, coal and asbestos. By the midd...

    Authors: Ken Donaldson and Anthony Seaton

    Citation: Particle and Fibre Toxicology 2012 9:13

    Content type: Review

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  40. There is growing evidence that particulate air pollution derived from wood stoves causes acute inflammation in the respiratory system, increases the incidence of asthma and other allergic diseases, and increas...

    Authors: Ingunn Skogstad Riddervold, Jakob Hjort Bønløkke, Anna-Carin Olin, Therese Koops Grønborg, Vivi Schlünssen, Kristin Skogstrand, David Hougaard, Andreas Massling and Torben Sigsgaard

    Citation: Particle and Fibre Toxicology 2012 9:12

    Content type: Research

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  41. Polymer nanoparticles (PNP) are becoming increasingly important in nanomedicine and food-based applications. Size and surface characteristics are often considered to be important factors in the cellular intera...

    Authors: Sourav Bhattacharjee, Dmitry Ershov, Kleanthis Fytianos, Jasper van der Gucht, Gerrit M Alink, Ivonne M C M Rietjens, Antonius T M Marcelis and Han Zuilhof

    Citation: Particle and Fibre Toxicology 2012 9:11

    Content type: Research

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  42. Carbon nanotubes (CNT) and carbon nanofibers (CNF) are allotropes of carbon featuring fibrous morphology. The dimensions and high aspect ratio of CNT and CNF have prompted the comparison with naturally occurri...

    Authors: Ashley R Murray, Elena R Kisin, Alexey V Tkach, Naveena Yanamala, Robert Mercer, Shih-Houng Young, Bengt Fadeel, Valerian E Kagan and Anna A Shvedova

    Citation: Particle and Fibre Toxicology 2012 9:10

    Content type: Research

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  43. Inhalation of diesel exhaust impairs vascular function in man, by a mechanism that has yet to be fully established. We hypothesised that pulmonary exposure to diesel exhaust particles (DEP) would cause endothe...

    Authors: Sarah Robertson, Gillian A Gray, Rodger Duffin, Steven G McLean, Catherine A Shaw, Patrick WF Hadoke, David E Newby and Mark R Miller

    Citation: Particle and Fibre Toxicology 2012 9:9

    Content type: Research

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  44. Carbon nanotubes (CNT) are high aspect ratio nanoparticles with diameters in the nanometre range but lengths extending up to hundreds of microns. The structural similarities between CNT and asbestos have raise...

    Authors: Fiona A Murphy, Anja Schinwald, Craig A Poland and Ken Donaldson

    Citation: Particle and Fibre Toxicology 2012 9:8

    Content type: Research

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  45. Exposure to wood smoke is associated with respiratory symptoms, whereas knowledge on systemic effects is limited. We investigated effects on systemic inflammation, oxidative stress and microvascular function (...

    Authors: Lykke Forchhammer, Peter Møller, Ingunn Skogstad Riddervold, Jakob Bønløkke, Andreas Massling, Torben Sigsgaard and Steffen Loft

    Citation: Particle and Fibre Toxicology 2012 9:7

    Content type: Research

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  46. Exposure to respirable crystalline silica particles, as opposed to amorphous silica, is associated with lung inflammation, pulmonary fibrosis (silicosis), and potentially with lung cancer. We used Affymetrix/G...

    Authors: Timothy N Perkins, Arti Shukla, Paul M Peeters, Jeremy L Steinbacher, Christopher C Landry, Sherrill A Lathrop, Chad Steele, Niki L Reynaert, Emiel FM Wouters and Brooke T Mossman

    Citation: Particle and Fibre Toxicology 2012 9:6

    Content type: Research

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  47. Widespread occupational exposure to carbon black nanoparticles (CBNPs) raises concerns over their safety. CBNPs are genotoxic in vitro but less is known about their genotoxicity in various organs in vivo.

    Authors: Julie A Bourdon, Anne T Saber, Nicklas R Jacobsen, Keld A Jensen, Anne M Madsen, Jacob S Lamson, Håkan Wallin, Peter Møller, Steffen Loft, Carole L Yauk and Ulla B Vogel

    Citation: Particle and Fibre Toxicology 2012 9:5

    Content type: Research

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  48. Little is known of how the toxicity of nanoparticles is affected by the incorporation in complex matrices. We compared the toxic effects of the titanium dioxide nanoparticle UV-Titan L181 (NanoTiO2), pure or embe...

    Authors: Anne Thoustrup Saber, Nicklas Raun Jacobsen, Alicia Mortensen, Józef Szarek, Petra Jackson, Anne Mette Madsen, Keld Alstrup Jensen, Ismo K Koponen, Gunnar Brunborg, Kristine Bjerve Gützkow, Ulla Vogel and Håkan Wallin

    Citation: Particle and Fibre Toxicology 2012 9:4

    Content type: Research

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  49. Due to the rising use of nanomaterials (NMs), there is concern that NMs induce undesirable biological effects because of their unique physicochemical properties. Recently, we reported that amorphous silica nan...

    Authors: Toshiro Hirai, Tomoaki Yoshikawa, Hiromi Nabeshi, Tokuyuki Yoshida, Saeko Tochigi, Ko-ichi Ichihashi, Miyuki Uji, Takanori Akase, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Norio Itoh, Shin-ichi Tsunoda, Yasuo Yoshioka and Yasuo Tsutsumi

    Citation: Particle and Fibre Toxicology 2012 9:3

    Content type: Research

    Published on:

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