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  1. Nanoparticles have become a key technology in multiple industries. However, there are growing reports of the toxicity of nanomaterials to humans. In particular, nanomaterials have been linked to lung diseases....

    Authors: Yang Sun, Feng Guo, Zhen Zou, Chenggang Li, Xiaoxu Hong, Yan Zhao, Chenxuan Wang, Hongliang Wang, Haolin Liu, Peng Yang, Zongsheng Han, Kangtai Liu, Keiji Kuba, Bin Song, Jinming Gao, Ziyao Mo…
    Citation: Particle and Fibre Toxicology 2015 12:4
    Content type: Research Published on:

  2. Nanomaterials hold great promise for applications in the delivery of various molecules with poor cell penetration, yet its potential for delivery of metal ions is rarely considered. Particularly, there is limi...

    Authors: Ying Zhu, Yu Zhang, Guosheng Shi, Jinrong Yang, Jichao Zhang, Wenxin Li, Aiguo Li, Renzhong Tai, Haiping Fang, Chunhai Fan and Qing Huang
    Citation: Particle and Fibre Toxicology 2015 12:2
    Content type: Research Published on:

  3. The lung epithelium constitutes the first barrier against invading pathogens and also a major surface potentially exposed to nanoparticles. In order to ensure and preserve lung epithelial barrier function, the...

    Authors: Mathilde Delaval, Sonja Boland, Brigitte Solhonne, Marie-Anne Nicola, Stéphane Mornet, Armelle Baeza-Squiban, Jean-Michel Sallenave and Ignacio Garcia-Verdugo
    Citation: Particle and Fibre Toxicology 2015 12:1
    Content type: Research Published on:

  4. In general the prediction of the toxicity and therapeutic efficacy of engineered nanoparticles in humans is initially determined using in vitro static cell culture assays. However, such test systems may not be su...

    Authors: Christian Freese, Daniel Schreiner, Laura Anspach, Christoph Bantz, Michael Maskos, Ronald E Unger and C James Kirkpatrick
    Citation: Particle and Fibre Toxicology 2014 11:68
    Content type: Research Published on:

  5. Convincing evidence suggests that poorly soluble low-toxicity particles (PSP) exert two unifying major modes of action (MoA), in which one appears to be deposition-related acute, whilst the other is retention-...

    Authors: Jürgen Pauluhn
    Citation: Particle and Fibre Toxicology 2014 11:72
    Content type: Review Published on:

  6. The hemolytic activity of inhaled particles such as silica has been widely investigated in the past and represents a usual toxicological endpoint to characterize particle reactivity despite the fact that red b...

    Authors: Cristina Pavan, Virginie Rabolli, Maura Tomatis, Bice Fubini and Dominique Lison
    Citation: Particle and Fibre Toxicology 2014 11:76
    Content type: Research Published on:

  7. Diesel exhaust particles (DEP) are major constituents of ambient air pollution and their adverse health effect is an area of intensive investigations. With respect to the immune system, DEP have attracted sign...

    Authors: Marina Pierdominici, Angela Maselli, Serena Cecchetti, Antonella Tinari, Arianna Mastrofrancesco, Michela Alfè, Valentina Gargiulo, Carlo Beatrice, Gabriele Di Blasio, Giulia Carpinelli, Elena Ortona, Antonello Giovannetti and Silvana Fiorito
    Citation: Particle and Fibre Toxicology 2014 11:74
    Content type: Research Published on:

  8. Although major concerns exist regarding the potential consequences of human exposures to nanoscale carbon black (CB) particles, limited human toxicological data is currently available. The purpose of this stud...

    Authors: Rong Zhang, Yufei Dai, Xiao Zhang, Yong Niu, Tao Meng, Yuanyuan Li, Huawei Duan, Ping Bin, Meng Ye, Xiaowei Jia, Meili Shen, Shanfa Yu, Xiaofa Yang, Weimin Gao and Yuxin Zheng
    Citation: Particle and Fibre Toxicology 2014 11:73
    Content type: Research Published on:

  9. Ge-imogolites are short aluminogermanate tubular nanomaterials with attractive prospected industrial applications. In view of their nano-scale dimensions and high aspect ratio, they should be examined for thei...

    Authors: Sybille van den Brule, Emilie Beckers, Perrine Chaurand, Wei Liu, Saloua Ibouraadaten, Mihaly Palmai-Pallag, Francine Uwambayinema, Yousof Yakoub, Astrid Avellan, Clément Levard, Vincent Haufroid, Etienne Marbaix, Antoine Thill, Dominique Lison and Jérôme Rose
    Citation: Particle and Fibre Toxicology 2014 11:67
    Content type: Research Published on:

  10. Airborne exposure to nanomaterials from unintended occupational or environmental exposures or as a consequence of product use may lead to adverse health effects. Numerous studies have focused on single-walled ...

    Authors: Pallab Sanpui, Xiao Zheng, Julia C Loeb, Joseph H Bisesi Jr, Iftheker A Khan, A R M Nabiul Afrooz, Keira Liu, Appala Raju Badireddy, Mark R Wiesner, P Lee Ferguson, Navid B Saleh, John A Lednicky and Tara Sabo-Attwood
    Citation: Particle and Fibre Toxicology 2014 11:66
    Content type: Research Published on:

  11. Inflammasome-activated IL-1β plays a major role in lung neutrophilic inflammation induced by inhaled silica. However, the exact mechanisms that contribute to the initial production of precursor IL-1β (pro-IL-1...

    Authors: Virginie Rabolli, Anissa Alami Badissi, Raynal Devosse, Francine Uwambayinema, Yousof Yakoub, Mihaly Palmai-Pallag, Astrid Lebrun, Valentin De Gussem, Isabelle Couillin, Bernard Ryffel, Etienne Marbaix, Dominique Lison and François Huaux
    Citation: Particle and Fibre Toxicology 2014 11:69
    Content type: Research Published on:

  12. Changes in DNA methylation have been associated with traffic-related air pollution in observational studies, but the specific mechanisms and temporal dynamics therein have not been explored in a controlled stu...

    Authors: Ruiwei Jiang, Meaghan J Jones, Francesco Sava, Michael S Kobor and Christopher Carlsten
    Citation: Particle and Fibre Toxicology 2014 11:71
    Content type: Research Published on:

  13. Traffic-related air pollution may contribute to cardiovascular morbidity. In urban areas, exposures during physical activity are of interest owing to increased breathing rates and close proximity to vehicle em...

    Authors: Scott Weichenthal, Marianne Hatzopoulou and Mark S Goldberg
    Citation: Particle and Fibre Toxicology 2014 11:70
    Content type: Research Published on:

  14. In light of recent developments in nanotechnologies, interest is growing to better comprehend the interaction of nanoparticles with body tissues, in particular within the cardiovascular system. Attention has r...

    Authors: Monia Savi, Stefano Rossi, Leonardo Bocchi, Laura Gennaccaro, Francesca Cacciani, Alessio Perotti, Davide Amidani, Rossella Alinovi, Matteo Goldoni, Irene Aliatis, Pier Paolo Lottici, Danilo Bersani, Marco Campanini, Silvana Pinelli, Marta Petyx, Caterina Frati…
    Citation: Particle and Fibre Toxicology 2014 11:63
    Content type: Research Published on:

  15. Myocardial infarction is the leading cause of death in fire fighters and has been linked with exposure to air pollution and fire suppression duties. We therefore investigated the effects of wood smoke exposure...

    Authors: Amanda L Hunter, Jon Unosson, Jenny A Bosson, Jeremy P Langrish, Jamshid Pourazar, Jennifer B Raftis, Mark R Miller, Andrew J Lucking, Christoffer Boman, Robin Nyström, Kenneth Donaldson, Andrew D Flapan, Anoop SV Shah, Louis Pung, Ioannis Sadiktsis, Silvia Masala…
    Citation: Particle and Fibre Toxicology 2014 11:62
    Content type: Research Published on:

  16. Nanosilver is one of the most commonly used engineered nanomaterials (ENMs). In our study we focused on assessing the size-dependence of the toxicity of nanosilver (Ag ENMs), utilising materials of three sizes...

    Authors: Anna Huk, Emilia Izak-Nau, Bogumila Reidy, Matthew Boyles, Albert Duschl, Iseult Lynch and Maria Dušinska
    Citation: Particle and Fibre Toxicology 2014 11:65
    Content type: Research Published on:

  17. The complement system is a key component of innate immunity implicated in the neutralization and clearance of invading pathogens. Dextran coated superparamagnetic iron oxide (SPIO) nanoparticle is a promising ...

    Authors: Nirmal K Banda, Gaurav Mehta, Ying Chao, Guankui Wang, Swetha Inturi, Liliane Fossati-Jimack, Marina Botto, LinPing Wu, Seyed Moein Moghimi and Dmitri Simberg
    Citation: Particle and Fibre Toxicology 2014 11:64
    Content type: Research Published on:

  18. Ambient air particulate matter (PM) is increasingly considered to be a causal factor evoking severe adverse health effects. People spend the majority of their time indoors, which should be taken into account e...

    Authors: Mikko S Happo, Olli Sippula, Pasi I Jalava, Helena Rintala, Ari Leskinen, Mika Komppula, Kari Kuuspalo, Santtu Mikkonen, Kari Lehtinen, Jorma Jokiniemi and Maija-Riitta Hirvonen
    Citation: Particle and Fibre Toxicology 2014 11:60
    Content type: Research Published on:

  19. Biological effects of tailor-made multi-walled carbon nanotubes (MWCNTs) without functionalization were investigated in vivo in a two-year carcinogenicity study. In the past, intraperitoneal carcinogenicity studi...

    Authors: Susanne Rittinghausen, Anja Hackbarth, Otto Creutzenberg, Heinrich Ernst, Uwe Heinrich, Albrecht Leonhardt and Dirk Schaudien
    Citation: Particle and Fibre Toxicology 2014 11:59
    Content type: Research Published on:

  20. Mineral particles in the lung cause inflammation and silicosis. In myeloid and bronchial epithelial cells the inflammasome plays a role in responses to crystalline silica. Thioredoxin (TRX) and its inhibitory ...

    Authors: Paul M Peeters, Irene M J Eurlings, Timothy N Perkins, Emiel F Wouters, Roel P F Schins, Paul J A Borm, Wolfgang Drommer, Niki L Reynaert and Catrin Albrecht
    Citation: Particle and Fibre Toxicology 2014 11:58
    Content type: Research Published on:

  21. Pulmonary exposure to nanoparticles (NPs) may affect, in addition to pulmonary toxicity, the cardiovascular system such as procoagulant effects, vascular dysfunction and progression of atherosclerosis. However...

    Authors: Katrien Luyts, Stijn Smulders, Dorota Napierska, Soetkin Van kerckhoven, Katrien Poels, Hans Scheers, Bianca Hemmeryckx, Ben Nemery, Marc F Hoylaerts and Peter H M Hoet
    Citation: Particle and Fibre Toxicology 2014 11:61
    Content type: Research Published on:

  22. For many individuals, daily commuting activities on roadways account for a substantial proportion of total exposure, as well as peak-level exposures, to traffic-related air pollutants (TRAPS) including ultrafi...

    Authors: Robert J Laumbach, Howard M Kipen, Susan Ko, Kathie Kelly-McNeil, Clarimel Cepeda, Ashley Pettit, Pamela Ohman-Strickland, Lin Zhang, Junfeng Zhang, Jicheng Gong, Manoj Veleeparambil and Andrew J Gow
    Citation: Particle and Fibre Toxicology 2014 11:45
    Content type: Research Published on:

  23. Exposures to elevated levels of particulate matter (PM) enhance severity of influenza virus infection in infants. The biological mechanism responsible for this phenomenon is unknown. The recent identification ...

    Authors: Greg I Lee, Jordy Saravia, Dahui You, Bishwas Shrestha, Sridhar Jaligama, Valerie Y Hebert, Tammy R Dugas and Stephania A Cormier
    Citation: Particle and Fibre Toxicology 2014 11:57
    Content type: Research Published on:

  24. Prior experimental and epidemiologic data support a link between exposure to fine ambient particulate matter (<2.5 μm in aerodynamic diameter, PM2.5) and development of insulin resistance/Type II diabetes mellitu...

    Authors: Cuiqing Liu, Laura K Fonken, Aixia Wang, Andrei Maiseyeu, Yuntao Bai, Tse-Yao Wang, Santosh Maurya, Yi-An Ko, Muthu Periasamy, Timothy Dvonch, Masako Morishita, Robert D Brook, Jack Harkema, Zhekang Ying, Bhramar Mukherjee, Qinghua Sun…
    Citation: Particle and Fibre Toxicology 2014 11:53
    Content type: Research Published on:

  25. Nanoparticulate barium sulfate has potential novel applications and wide use in the polymer and paint industries. A short-term inhalation study on barium sulfate nanoparticles (BaSO4 NPs) was previously published...

    Authors: Nagarjun Konduru, Jana Keller, Lan Ma-Hock, Sibylle Gröters, Robert Landsiedel, Thomas C Donaghey, Joseph D Brain, Wendel Wohlleben and Ramon M Molina
    Citation: Particle and Fibre Toxicology 2014 11:55
    Content type: Research Published on:

  26. The liver has a crucial role in metabolic homeostasis as well as being the principal detoxification centre of the body, removing xenobiotics and waste products which could potentially include some nanomaterial...

    Authors: Ali Kermanizadeh, Mille L hr, Martin Roursgaard, Simon Messner, Patrina Gunness, Jens M Kelm, Peter Møller, Vicki Stone and Steffen Loft
    Citation: Particle and Fibre Toxicology 2014 11:56
    Content type: Research Published on:

  27. Studies have shown a relationship between air pollution and increased risk of cardiovascular morbidity and mortality. Due to the complexity of ambient air pollution composition, recent studies have examined th...

    Authors: Nicole Kurhanewicz, Rachel McIntosh-Kastrinsky, Haiyan Tong, Leon Walsh, Aimen K Farraj and Mehdi S Hazari
    Citation: Particle and Fibre Toxicology 2014 11:54
    Content type: Research Published on:

  28. Carbon nanotubes (CNT) represent a great promise for technological and industrial development but serious concerns on their health effects have also emerged. Rod-shaped CNT are, in fact, able to induce asbesto...

    Authors: Elina M Rydman, Marit Ilves, Antti J Koivisto, Pia A S Kinaret, Vittorio Fortino, Terhi S Savinko, Maili T Lehto, Ville Pulkkinen, Minnamari Vippola, Kaarle J Hämeri, Sampsa Matikainen, Henrik Wolff, Kai M Savolainen, Dario Greco and Harri Alenius
    Citation: Particle and Fibre Toxicology 2014 11:48
    Content type: Research Published on:

  29. Silver nanowires (Ag NWs) are increasingly being used to produce touchscreens for smart phones and computers. When applied in a thin film over a plastic substrate, Ag NWs create a transparent, highly-conductiv...

    Authors: Rona M Silva, Jingyi Xu, Clare Saiki, Donald S Anderson, Lisa M Franzi, Chris D Vulpe, Benjamin Gilbert, Laura S Van Winkle and Kent E Pinkerton
    Citation: Particle and Fibre Toxicology 2014 11:52
    Content type: Research Published on:

  30. Exposure to ambient particulate matter (PM) has been associated with reduced lung function. Elemental components of PM have been suggested to have critical roles in PM toxicity, but their contribution to respi...

    Authors: Andrea A Baccarelli, Yinan Zheng, Xiao Zhang, Dou Chang, Lei Liu, Katherine Rose Wolf, Zhou Zhang, John P McCracken, Anaité Díaz, Pier Alberto Bertazzi, Joel Schwartz, Sheng Wang, Choong-Min Kang, Petros Koutrakis and Lifang Hou
    Citation: Particle and Fibre Toxicology 2014 11:51
    Content type: Research Published on:

  31. Given that the effects of ultrafine fractions (<0.1 μm) on ischemic heart diseases (IHD) and other cardiovascular diseases are gaining attention, this study is aimed to explore the influence of silica nanopart...

    Authors: Junchao Duan, Yongbo Yu, Yang Yu, Yang Li, Peili Huang, Xianqing Zhou, Shuangqing Peng and Zhiwei Sun
    Citation: Particle and Fibre Toxicology 2014 11:50
    Content type: Research Published on:

  32. Toxicity testing the rapidly growing number of nanomaterials requires large scale use of in vitro systems under the presumption that these systems are sufficiently predictive or descriptive of responses in in ...

    Authors: Justin G Teeguarden, Vladimir B Mikheev, Kevin R Minard, William C Forsythe, Wei Wang, Gaurav Sharma, Norman Karin, Susan C Tilton, Katrina M Waters, Bahman Asgharian, Owen R Price, Joel G Pounds and Brian D Thrall
    Citation: Particle and Fibre Toxicology 2014 11:46
    Content type: Research Published on:

  33. The challenge remains to reliably mimic human exposure to high aspect ratio nanoparticles (HARN) via inhalation. Sophisticated, multi-cellular in vitro models are a particular advantageous solution to this issue,...

    Authors: Carola Endes, Otmar Schmid, Calum Kinnear, Silvana Mueller, Sandra Camarero-Espinosa, Dimitri Vanhecke, E Johan Foster, Alke Petri-Fink, Barbara Rothen-Rutishauser, Christoph Weder and Martin JD Clift
    Citation: Particle and Fibre Toxicology 2014 11:40
    Content type: Research Published on:

  34. Although silver nanoparticles are currently used in more than 400 consumer products, it is not clear to what extent they induce adverse effects after inhalation during production and use. In this study, we det...

    Authors: Hedwig M Braakhuis, Ilse Gosens, Petra Krystek, John AF Boere, Flemming R Cassee, Paul HB Fokkens, Jan Andries Post, Henk van Loveren and Margriet VDZ Park
    Citation: Particle and Fibre Toxicology 2014 11:49
    Content type: Research Published on:

  35. Studies provide compelling evidences for particulate matter (PM) associated cardiovascular health effects. Elderly individuals, particularly those with preexisting conditions like hypertension are regarded to ...

    Authors: Swapna Upadhyay, Tobias Stoeger, Leema George, Mette C Schladweiler, Urmila Kodavanti, Koustav Ganguly and Holger Schulz
    Citation: Particle and Fibre Toxicology 2014 11:36
    Content type: Research Published on:

  36. Due to the increased application of titanium dioxide nanoparticles (TiO2 NPs) in the food industry and daily life, their potential toxic effects in humans and animals h...

    Authors: Xiaoyang Zhao, Lei Sheng, Ling Wang, Jie Hong, Xiaohong Yu, Xuezi Sang, Qingqing Sun, Yuguan Ze and Fashui Hong
    Citation: Particle and Fibre Toxicology 2014 11:47
    Content type: Research Published on:

    The Retraction Note to this article has been published in Particle and Fibre Toxicology 2015 12:23

  37. Epidemiological and experimental studies suggest that exposure to ultrafine particles (UFP) might aggravate the allergic inflammation of the lung in asthmatics.

    Authors: Frank Schaumann, Cornelia Frömke, Dorothea Dijkstra, Francesca Alessandrini, Horst Windt, Erwin Karg, Meike Müller, Carla Winkler, Armin Braun, Armin Koch, Jens Michael Hohlfeld, Heidrun Behrendt, Otmar Schmid, Wolfgang Koch, Holger Schulz and Norbert Krug
    Citation: Particle and Fibre Toxicology 2014 11:39
    Content type: Research Published on:

  38. There is evidence that nanoparticles (NP) cross epithelial and endothelial body barriers. We hypothesized that gold (Au) NP, once in the blood circulation of pregnant rats, will cross the placental barrier dur...

    Authors: Manuela Semmler-Behnke, Jens Lipka, Alexander Wenk, Stephanie Hirn, Martin Schäffler, Furong Tian, Günter Schmid, Günter Oberdörster and Wolfgang G Kreyling
    Citation: Particle and Fibre Toxicology 2014 11:33
    Content type: Research Published on:

  39. Nanoparticle pharmacokinetics and biological effects are influenced by several factors. We assessed the effects of amorphous SiO2 coating on the pharmacokinetics of zinc oxide nanoparticles (ZnO NPs) following in...

    Authors: Nagarjun V Konduru, Kimberly M Murdaugh, Georgios A Sotiriou, Thomas C Donaghey, Philip Demokritou, Joseph D Brain and Ramon M Molina
    Citation: Particle and Fibre Toxicology 2014 11:44
    Content type: Research Published on:

  40. Surface modification strategies to reduce engineered nanomaterial (ENM) bioactivity have been used successfully in carbon nanotubes. This study examined the toxicity and inflammatory potential for two surface ...

    Authors: Raymond F Hamilton, Nianqiang Wu, Chengcheng Xiang, Ming Li, Feng Yang, Michael Wolfarth, Dale W Porter and Andrij Holian
    Citation: Particle and Fibre Toxicology 2014 11:43
    Content type: Research Published on:

  41. The rapid expansion of manufacturing and use of nano-sized materials fuels the demand for fast and reliable assays to identify their potential hazardous properties and underlying mechanisms. The ToxTracker ass...

    Authors: Hanna L Karlsson, Anda R Gliga, Fabienne MGR Calléja, Cátia SAG Gonçalves, Inger Odnevall Wallinder, Harry Vrieling, Bengt Fadeel and Giel Hendriks
    Citation: Particle and Fibre Toxicology 2014 11:41
    Content type: Research Published on:

  42. The potential effects of combinations of dilute whole diesel exhaust (DE) and ozone (O3), each a common component of ambient airborne pollutant mixtures, on lung function were examined. Healthy young human volunt...

    Authors: Michael C Madden, Tina Stevens, Martin Case, Michael Schmitt, David Diaz-Sanchez, Maryann Bassett, Tracey S Montilla, Jon Berntsen and Robert B Devlin
    Citation: Particle and Fibre Toxicology 2014 11:37
    Content type: Research Published on:

  44. Welding fume is an exposure that consists of a mixture of metal-rich particulate matter with gases (ozone, carbon monoxide) and/or vapors (VOCs). Data suggests that welders are immune compromised. Given the in...

    Authors: Aaron Erdely, James M Antonini, Shih-Houng Young, Michael L Kashon, Ja K Gu, Tracy Hulderman, Rebecca Salmen, Terence Meighan, Jenny R Roberts and Patti C Zeidler-Erdely
    Citation: Particle and Fibre Toxicology 2014 11:34
    Content type: Research Published on:

  45. Metal oxide nanoparticles such as ZnO are used in sunscreens as they improve their optical properties against the UV-light that causes dermal damage and skin cancer. However, the hazardous properties of the pa...

    Authors: Marit Ilves, Jaana Palomäki, Minnamari Vippola, Maili Lehto, Kai Savolainen, Terhi Savinko and Harri Alenius
    Citation: Particle and Fibre Toxicology 2014 11:38
    Content type: Research Published on:

  47. Diabetes may confer an increased risk for the cardiovascular health effects of particulate air pollution, but few human clinical studies of air pollution have included people with diabetes. Ultrafine particles...

    Authors: Rathin Vora, Wojciech Zareba, Mark J Utell, Anthony P Pietropaoli, David Chalupa, Erika L Little, David Oakes, Jan Bausch, Jelani Wiltshire and Mark W Frampton
    Citation: Particle and Fibre Toxicology 2014 11:31
    Content type: Research Published on:

  48. The aim of this study was to obtain kinetic data that can be used in human risk assessment of titanium dioxide nanomaterials.

    Authors: Liesbeth Geraets, Agnes G Oomen, Petra Krystek, Nicklas R Jacobsen, HÃ¥kan Wallin, Michel Laurentie, Henny W Verharen, Esther FA Brandon and Wim H de Jong
    Citation: Particle and Fibre Toxicology 2014 11:30
    Content type: Research Published on:

  49. Emissions from a large peat fire in North Carolina in 2008 were associated with increased hospital admissions for asthma and the rate of heart failure in the exposed population. Peat fires often produce larger...

    Authors: Yong Ho Kim, Haiyan Tong, Mary Daniels, Elizabeth Boykin, Q Todd Krantz, John McGee, Michael Hays, Kasey Kovalcik, Janice A Dye and M Ian Gilmour
    Citation: Particle and Fibre Toxicology 2014 11:29
    Content type: Research Published on:

  50. In vivo studies have demonstrated the ability of multi-walled carbon nanotubes (MWCNT) to induce airway remodeling, a key feature of chronic respiratory diseases like asthma and chronic obstructive pulmonary dise...

    Authors: Salik Hussain, Stacey Sangtian, Shamika M Anderson, Ryan J Snyder, Jamie D Marshburn, Annette B Rice, James C Bonner and Stavros Garantziotis
    Citation: Particle and Fibre Toxicology 2014 11:28
    Content type: Research Published on:

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