Figure 4

Translocation of ¹⁹²Ir-UFP particles (upper panel) and ^99mTc-DTPA (lower panel) into perfusate of isolated perfused rat lung as a fraction of the deposited dose for inhaled particles and as fraction of the instilled dose for DTPA. Both control lungs (●) were used as well as lungs treated in-situ with H₂O₂ bolus 0.5 mM (O), histamine (1 μM) in perfusate (□) or 0,5 mM instilled into the lungs (■). A stabilisation period of 15 minutes is done before treatment and collection of samples are taken place every 15 minutes for translocation and lung markers detection. Values in the upper panel depict the mean and SD's of 3 or 4 experiments; values in the lower panel depict only the mean of 3 or 4 experiments indicating the trend.