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Table 2 Health effect parameters measured in lung lavage fluid of spontaneously hypertensive rats 8 h afterexposure to concentrated ambient particulate matter or clean air as a control.

From: Response of spontaneously hypertensive rats to inhalation of fine and ultrafine particles from traffic: experimental controlled study

  

fCAP (Site I)

u+fCAP (Site II)

  

Control (n = 40)

CAPs (n = 40)

Control (n = 64)

CAPs (n = 64)

Parameter

Units

Mean

95% CI

Mean

95% CI

Sign.

Mean

95% CI

Mean

95% CI

Sign.

ALP

U/L

57.0

52.0–62.1

51.6

44.9–58.3

 

26.7

23.4–30.0

26.1

22.9–29.2

 

LDH

U/L

66.3

62.2–70.4

67.6

63.3–72.0

 

55.7

49.5–61.9

52.5

50.3–54.8

 

Protein

mg/L

314

277.9–350.4

349

295.5–402.2

 

274.5

242–308

282.0

256–288

 

NAG

U/L

1.31

1.20–1.43

1.43

1.32–1.54

 

0.79

0.70–0.87

0.81

0.74–0.88

 

UA-B

umol/L

0.29

0.22–0.35

0.45

0.26–0.63

 

0.46

0.36–0.56

0.42

0.34–0.51

 

Total Glut.

umol/L

0.92

0.789–1.058

1.00

0.836–1.165

 

1.34

1.02–1.65

1.22

1.12–1.31

 

GSH

umol/L

0.155

0.099–0.211

0.244

0.158–0.329

 

0.39

0.21–0.57

0.31

0.22–0.40

 

GSSG:GSH

ratio

2.61

 

1.70

  

4.8

 

2.7

  

TNF-α

ng/ml

46.4

42.5–50.2

47.7

43.2–52.1

 

45.9

37.6–54.2

46.4

37.9–54.9

 

MIP-2

ng/ml

333

321–344

311

297–325

 

192.4

183–202

192.2

184–200

a

IL-1b

ng/ml

268

237–299

248

210–286

 

n.m.

 

n.m.

  

CC16

ng/ml

1.78

1.41–2.14

1.98

1.56–2.40

 

3.31

 

3.31

  

MDA

μmol/l

0.268

0.200–0.335

0.237

0.201–0.273

 

0.407

0.341–0.473

0.341

0.281–0.401

*

HO-1

ng/ml

0.393

0.296–0.491

0.521

0.347–0.696

 

0.517

0.418–0.615

0.664

0.547–0.781

**

Macrophages

%

90.5

89.2–91.8

88.7

87.2–90.1

 

94.4

93.1–95.6

94.2

93.0–95.3

 

Neutrophils

%

4.95

3.70–6.20

4.76

3.54–5.99

 

1.95

1.26–2.64

1.95

1.37–2.54

 

Eosinophils

%

0.60

0.44–0.76

0.44

0.28–0.61

 

0.42

0.23–0.61

0.34

0.21–0.46

 

Lymfocytes

%

1.05

0.83–1.27

1.43

1.08–1.77

 

2.60

1.93–3.28

2.99

2.11–3.88

 

Cell count

*10e3

541

481–600

528

473–583

 

469

381–556

417

349–485

 

Macrophages

*10e3

489

435–543

461

415–507

 

445

358–532

394

327–461

 

Neutrophils

*10e3

25.70

17.2–34.2

26.80

17.8–35.9

 

7.88

4.36–11.41

7.39

5.23–9.52

 

Eosinophils

*10e3

3.04

2.24–3.84

2.60

1.47–3.73

 

2.02

0.73–3.31

1.46

0.80–2.11

 

Lymfocytes

*10e3

5.50

4.20–6.84

7.70

5.60–9.81

P = 0.06

10.41

7.43–13.40

11.87

8.01–15.73

 
  1. **p < 0.01
  2. a n = 32
  3. ALP, alkaline phosphatase; LDH, lactate dehydrogenase; NAG, N-acetyl glucosaminidase; UA, uric acid, Total Glut., total glutathione; GSH, reduced glutathione;GSSG, oxidized glutathione; TNF-α, tumor necrotic factor; MIP, macrophage inhibiting factor;IL, interleukine, CC16, Clara cell protein; MDA, malondialdehyde; HO-1, heme oxygenase; CI, confidence interval; fCAP, fine concentrated ambient particulate matter; n.m., not measured; u+fCAP, ultrafine plus fine concentrated ambient particulate matter.
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Particle and Fibre Toxicology

ISSN: 1743-8977

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