Table 5 Results of bacterial gene point mutation assay. Cerium oxide – non-nanoparticulate. Summary of mean revertant colonies obtained

Substance

Dose Level (μg/plate)

TA100

TA1535

TA102

TA98

TA1537

Mean ± S.D.

Mean ± S.D.

Mean ± S.D.

Mean ± S.D.

Mean ± S.D.

(-S9)

(+S9)

(-S9)

(+S9)

(-S9)

(+S9)

(-S9)

(+S9)

(-S9)

(+S9)

DMSO

100 μl

93 ± 16

105 ± 13

27 ± 7

9 ± 1

345 ± 17

374 ± 13

20 ± 3

27 ± 7

8 ± 3

13 ± 4

Cerium Oxide Non-nano

50

87 ± 10

115 ± 10

32 ± 2

11 ± 7

349 ± 42

352 ± 31

16 ± 7

23 ± 2

15 ± 4

19 ± 4

150

95 ± 4

91 ± 8

28 ± 7

14 ± 2

343 ± 20

397 ± 21

20 ± 3

23 ± 2

8 ± 4

19 ± 5

500

94 ± 13

89 ± 4

37 ± 5

9 ± 1

349 ± 27

364 ± 23

18 ± 2

29 ± 3

9 ± 1

17 ± 3

1500

82 ± 2

99 ± 2

33 ± 12

9 ± 3

351 ± 22

380 ± 10

17 ± 2

28 ± 4

8 ± 4

21 ± 6

5000

107 ± 2

97 ± 13

26 ± 4

10 ± 2

350 ± 49

382 ± 21

18 ± 4

23 ± 6

15 ± 5

19 ± 3