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Table 1 Immunoractivity of investigated antibodies in 15 Air and DE paired subjects participated in study.

From: Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium

Immunoreactivity

Air

Diesel

p value

EGFR

0.240 (0.100–0.370)

0.690 (0.210–1.960)

p = 0.004

Tyr 845

0.220 (0.027–0.520)

0.460 (0.160–1.030)

p = 0.1

Tyr 992

0.450 (0.320–0.580)

0.530 (0.220–1.540)

p = 0.14

Tyr 1068

0.015 (0.002–0.250)

0.180 (0.013–0.550)

p = 0.18

Tyr 1110

1.090 (0.560–2.140)

1.780 (0.980–2.200)

p = 0.39

Tyr 1173

2.230 (1.380–2.890)

3.160 (1.800–5.070)

p = 0.02

Tyr 416

0.033 (0.001–0.120)

0.016 (0.003–0.800)

p = 0.13

MEK 1, 2

1.330 (0.310–2.670)

1.410 (0.630–4.440)

p = 0.28

ERK 1, 2

0.140 (0.024–0.320)

0.160 (0.045–0.650)

p = 0.14

  1. Two sections from each biopsy and exposure were evaluated during investigation of each antibody.
  2. Bronchial epithelium expression of EGFR, Tyrosine sites and downstream signalling immunoreactivity is given as percentage (%) positively stained area of the total measured epithelial area. All values are quoted as medians with inter-quartile range. Statistical comparisons by Wilcoxon's paired rank test.