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Table 1 Summary of the observed effects caused by TiO2- and hematite-NP

From: Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells

 

TiO2-NP

Hematite-NP

Genotoxicity (Comet assay: DNA breakage)

-

+

Cytotoxicity (Trypan blue assay)

- (+)* 1

+

Acellular radical formation (ESR)

↑

↓ (↑)*2

Intracellular radical formation (H2DCFDA)

↑

delayed

Oxidative DNA-damage (8-OHdG)

+

-

  1. *1 cytotoxicity negative in BEAS-2B and positive in IMR-90 cells
  2. *2 elevated radical formation under reducing conditions
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Particle and Fibre Toxicology

ISSN: 1743-8977

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