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Table 2 Functional analysis of probes that differ according to factor Genotype.*

From: Toxicogenomic analysis of susceptibility to inhaled urban particulate matter in mice with chronic lung inflammation

Functional term

Number of genes

% of total

P-value

immune system process

167

9.12%

4.19 × 10-27

antigen processing and presentation

34

1.86%

1.61 × 10-15

cell activation

56

3.06%

4.48 × 10-9

response to wounding

66

3.60%

4.55 × 10-9

leukocyte activation

53

2.89%

6.90 × 10-9

defence response

81

4.42%

3.19 × 10-9

response to external stimulus

87

4.75%

3.48 × 10-8

cytoskeleton organization and biogenesis

87

4.75%

6.72 × 10-8

hemopoietic or lymphoid organ development

54

2.85%

5.14 × 10-7

inflammatory response

47

2.57%

1.28 × 10-6

taxis

29

1.58%

4.19 × 10-6

mast cell activation

9

0.49%

1.45 × 10-5

lysosome organization and biogenesis

9

0.49%

2.83 × 10-5

cell division

44

2.40%

8.12 × 10-5

  1. * DAVID functional annotation analysis http://david.abcc.ncifcrf.gov/home.jsp was carried out using the list of the genes responding according to factor Genotype common to all treatment groups (1864 probes; 1831 unique DAVID IDs), with the Agilent Mouse Microarray G4121A probe list serving as background. Representative enriched terms selected from the top 50 of 278 gene ontology terms with a modified Fisher's Exact p < 0.05 are displayed.