Figure 6From: Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms Induction of NFκB signaling after particle treatment. NR8383 cells were treated with particles as indicated in concentrations of 40 μg/cm2 for 1 h. Compared to (A) untreated AM, (B) DQ12-treated cells show the strongest nuclear staining, while (C) fTiO2 and (D) ufTiO2 particles demonstrate a lower nuclear staining. Original magnification: 400-fold (Zeiss Axio Observer.D1).Back to article page