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Table 2 Top 10 genes affected by 24 h exposure to silica particles in BEAS 2B

From: Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells

Gene Name (Abbreviation)

Fold Changea

 

Cristobalite

Amorphous

 

75 b

150 b

150 b

Up-regulated â–²

   

Myxovirus (influenza virus) resistance 2 (mouse) (MX2)

20.86

73.76

22.33

Matrix metallopeptidase 1 (interstitial collagenase) (MMP1)

16.12

44.68

18.75

Sodium Channel, voltage-gated, type III, beta (SCN3B)

15.33

20.54

NC

2'-5'-oligoadenylate-synthetase 2, 69/71kDa (OAS2)

13.56

34.77

12.17

Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) (MX1)

9.61

23.33

8.72

Interferon-induced protein 44-like (IFI44L)

7.64

22.82

8.63

Interferon-induced protein 44 (IFI44)

7.51

19.90

8.24

B-cell Linker (BLNK)

7.24

9.32

NC

BTG family, member 2 (BTG2)

7.22

8.56

NC

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)

7.19

11.05

NC

2'-5'-oligoadenylate synthetase 1, 40/46kDa (OAS1)

7.09

20.53

6.75

Interferon, alpha-inducible protein 27 (IFI27)

6.59

17.62

6.15

2'-5'-oligoadenylate synthetase-like (OASL)

6.80

18.85

6.92

Radical S-adenosyl methionine domain containing (RSAD1)

5.45

23.25

6.09

Interleukin 24 (IL24)

3.88

8.54

6.47

Down-regulated â–¼

   

Collagen, type I, alpha 2 (COL1A2)

6.08

10.86

2.12

Hypoxia inducible factor 3, alpha subunit (HIF3A)

4.51

7.18

3.94

Collagen, type I, alpha 1 (COL1A1)

4.17

5.52

NC

Methyltransferase like 7A (METTL7A)

4.11

5.67

2.89

Cytochrome P450, family 4, subfamily B, polypeptide 1 (CYP4B1)

3.93

5.55

3.07

Olfactomedin-like 3 (OLFML3)

3.91

5.28

2.06

Mitogen-activated protein kinase kinase 6 (MAP2K6)

3.86

4.78

3.21

Collagen, type XI, alpha 1 (COL11A1)

3.85

5.46

NC

Potassium inwardly-rectifying channel, subfamily J, member 16 (KCNJ16)

3.78

7.11

3.49

Cannabinoid receptor 1 (brain) (CNR1)

3.75

5.44

3.48

Calcium channel, voltage-dependent, alpha 2/delta subunit 3 (CACNA2D3)

3.53

3.49

2.65

Solute carrier family 38, member 4 (SLC38A4)

3.16

3.76

2.65

Leucine rich repeat containing 17 (LRRC17)

3.14

5.07

3.61

Protocadherin 9 (PCDH9)

2.98

3.69

2.65

  1. Top 10 genes in BEAS 2B cells up and down-regulated by 24-hour exposure to cristobalite silica at 75 and 150 × 106μm2/cm2 and amorphous silica particles at 150 × 106 μm2/cm2.
  2. a Fold change (mRNA) expression (p < 0.05) cut-off ≥ 2.0-fold compared to controls (n = 3).
  3. b Silica particle concentrations: (× 106μm2/cm2)
  4. NC = No Change
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Particle and Fibre Toxicology

ISSN: 1743-8977

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