From: Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP)
Inhalation studies | |||||||||||
Duration | CNT | Dose | Experimental model | Fibrosis | References | ||||||
 | Type | Source | Length (μm) | Diameter (nm) | Other |  | Species | Strain | Methods |  |  |
1-28d | SWCNT | CNI | 0.1–1 | 0.8–1.2 |  | 5 mg/m3, 5 h/d, 4d | mouse | C57BL/6 | SSCK, SRS | + | [81] |
whole body | |||||||||||
1y | SWCNT | U | 1–3 | 65 |  | 5 mg/m3, 5 h/d, 4d | mouse | C57BL/6 | SSCK | + | [83] |
whole body | |||||||||||
2-12d | MWCNT-7 | HCC | / | / | Â | 10Â mg/m3, 5Â h/d | mouse | C57BL/6Â J | MTS | + | [84] |
whole body | |||||||||||
1 to 336d | MWCNT-7 | HCC | 4.3 | / | Â | 5Â mg/m3, 5Â h/d, 12d | mouse | C57BL/6Â J | SRS | + | [27] |
whole body | |||||||||||
17 m | MWCNT-7 | HCC | 1–6 | 40–90 |  | 5 mg/m3, 5 h/d, 5d/w | mouse | B6C3F1 | H&E | ↑ | [85] |
whole body | |||||||||||
90d | MWCNT-7 | HCC | 5.5–6.2 | 94–98 |  | 0.2–5 mg/m3, 5 h/d, 4d | rat | F344 | MTS | ++ | [86] |
whole body | |||||||||||
1d-14w | MWCNT | HMS | 0.3–50 | 30–50 |  | 1–30 mg/m3, 6 h/d | mouse | C57BL/6 | MTS | ++ | [87] |
nose inh | |||||||||||
90d | MWCNT | N | 0.1–10 | 5–15 |  | 0.1–2.5 mg/m3, | rat | Wistar | H&E | - | [88] |
6Â h/d, 5d/w, 13w | |||||||||||
nose inh | |||||||||||
90d | MWCNT | N | 0.1–10 | 5–15 |  | 0.1–2.5 mg/m3 | rat | SH | MTS, LS, GS | - | [89] |
6Â h/d, 5d/w, 13w | |||||||||||
nd inh |